CAJ | 학술논문

目的：比较三种不同胰岛素强化治疗方案对2型糖尿病（T2DM）疗效及安全性。方法将66例T2DM患者随机分为三组：门冬胰岛素30组（n＝22）、短效人胰岛素＋甘精胰岛素组（MDI）（n＝21）和短效人胰岛素持续皮下输注组（CSII）（n＝23）。观察三组治疗前后血糖的变化、血糖达标时间、胰岛素用量、低血糖发生率。结果三组方案治疗后血糖下降均有显著差异（P＜0．01），门冬胰岛素30组胰岛素用量较MDI组无显著差异（P＞0．05），较CSII组显著增加（P＜0．05），CSII组与MDI组胰岛素用量无显著差异（P＞0．05）；三组间血糖控制及达标时间、低血糖发生率均无显著差异（P＜0．05）。结论门冬胰岛素30组疗效及安全性较胰岛素泵或一天4次胰岛素皮下注射相当，且操作简单，依从性好，适合在基层医院推广。
목적：비교삼충불동이도소강화치료방안대2형당뇨병（T2DM）료효급안전성。방법장66례T2DM환자수궤분위삼조：문동이도소30조（n＝22）、단효인이도소＋감정이도소조（MDI）（n＝21）화단효인이도소지속피하수주조（CSII）（n＝23）。관찰삼조치료전후혈당적변화、혈당체표시간、이도소용량、저혈당발생솔。결과삼조방안치료후혈당하강균유현저차이（P＜0．01），문동이도소30조이도소용량교MDI조무현저차이（P＞0．05），교CSII조현저증가（P＜0．05），CSII조여MDI조이도소용량무현저차이（P＞0．05）；삼조간혈당공제급체표시간、저혈당발생솔균무현저차이（P＜0．05）。결론문동이도소30조료효급안전성교이도소빙혹일천4차이도소피하주사상당，차조작간단，의종성호，괄합재기층의원추엄。
Objective To observe the efficacy and safety of three different intensive insulin treatments for type 2 diabetes patients . Methods A total of 66 type 2 diabetes patients were randomly assigned into three groups:aspart 30 group(n=22),multiple daily sub-cutaneous pre-meal short-acting insulin and glargine at bedtime injection group (MDI) (n=21) and continuous subcutaneous short-acting insulin infusion group (CSII) (n=23).The level of fasting plasma glucose ,2-hour postprandial plasma glucose before and after the treatment,the time to achieve the glycemic control ,the insulin dose and the incidence of hypoglycemia were studied for comparison among three groups .Results There were statistically significant differences in plasma glucose before and after the treatment ( P<0.01).The insulin dose did not show difference between the aspart 30 and MDI group(P>0.05),and showed difference between the aspart 30 and CSII group(P<0.05),no difference between the MDI and CSII group (P>0.05).The plasma glucose after the treat-ment,the time to achieve the glycemic control,the incidence of hypoglycemia were not significantly different (P>0.05).Conclusions Aspart 30 is as effective and safe as insulin pump and MDI .And it was suitable for use in primary hospitals .