CAJ | 학술논문

目的：探讨护理干预对改良Hyper-CVAD/MA方案不良反应的影响。方法：将24例行改良Hyper-CVAD/MA方案治疗的高危淋巴瘤、白血病患者随机分为对照组和实验组各12例，对照组在化疗过程中采用常规护理措施，实验组在常规护理基础上实施针对性护理干预。结果：实验组患者胃肠道反应、感染发生率较对照组明显降低（ P＜0．05）；口腔黏膜炎和浅表静脉炎发生率与对照组比较均呈降低趋势，但差异无统计学意义（P＞0．05）；两组肝肾功能损害和药物外渗发生率比较差异无统计学意义（ P＞0．05）。结论：科学的护理干预能够有效降低改良Hyper-CVAD/MA方案引起的胃肠道反应和感染发生率。
목적：탐토호리간예대개량Hyper-CVAD/MA방안불량반응적영향。방법：장24례행개량Hyper-CVAD/MA방안치료적고위림파류、백혈병환자수궤분위대조조화실험조각12례，대조조재화료과정중채용상규호리조시，실험조재상규호리기출상실시침대성호리간예。결과：실험조환자위장도반응、감염발생솔교대조조명현강저（ P＜0．05）；구강점막염화천표정맥염발생솔여대조조비교균정강저추세，단차이무통계학의의（P＞0．05）；량조간신공능손해화약물외삼발생솔비교차이무통계학의의（ P＞0．05）。결론：과학적호리간예능구유효강저개량Hyper-CVAD/MA방안인기적위장도반응화감염발생솔。
Objective:To explore the influence of nursing intervention on the adverse reaction of modified Hyper -CVAD/MA regimen . Methods:24 high-risk patients who received the modified Hyper -CVAD/MA regimen for the treatment of lymphoma and leukemia were randomly divided into the control group and the experimental group (12 cases in each group).The routine nursing measures were taken in the course of chemotherapy in the control group and the pertinent nursing intervention was additionally implementated in the experimental group.Results:The gastrointestinal reaction and infection rate of the patients was significantly lower in the experimental group than the con -trol group (P<0.05);the incidence of oral mucositis and superficial thrombophlebitis decreased compared with the control group ,the difference between the two groups was not statistically significant ( P>0.05);there were not statistically signifcant differences in the com-parison of the damage of liver and kidney function of the patients and the incidence of drug extravasation between the two groups ( P>0.05).Conclusion:The scientific nursing intervention can effectively reduce gastrointestinal reaction and incidence of infection induced by modified Hyper-CVAD/MA regimen.