CAJ | 학술논문

目的：探讨抗心磷脂抗体阳性复发性流产患者妊娠前后凝血功能的动态变化。方法选取2010年1月至2012年1月在中山大学附属中山市人民医院就诊复发性流产患者，抗心磷脂抗体阳性患者46例为研究对象。选取同期就诊的抗心磷脂抗体阴性复发性流产患者23例及健康孕前检查妇女23例做为对照组。分别在患者计划妊娠时月经干净后3d、首次早早孕试验阳性当天及此后2周采血测定凝血功能指标。结果抗心磷脂抗体阳性复发性流产患者妊娠前与对照组比较vWF和TF升高(P＜0.01)；早早孕时与对照组和孕前比较vWF、TF、FPA及D-二聚均升高(P＜0.01)；早孕时与对照组和孕前比较vWF、TF、FPA及D-二聚体均升高(P＜0.01)，APTT降低(P＜0.01)。结论抗心磷脂抗体阳性复发性流产患者孕前即存在病理性高凝状态，妊娠后这种高凝状态进行性加重，呈动态变化过程。
목적：탐토항심린지항체양성복발성유산환자임신전후응혈공능적동태변화。방법선취2010년1월지2012년1월재중산대학부속중산시인민의원취진복발성유산환자，항심린지항체양성환자46례위연구대상。선취동기취진적항심린지항체음성복발성유산환자23례급건강잉전검사부녀23례주위대조조。분별재환자계화임신시월경간정후3d、수차조조잉시험양성당천급차후2주채혈측정응혈공능지표。결과항심린지항체양성복발성유산환자임신전여대조조비교vWF화TF승고(P＜0.01)；조조잉시여대조조화잉전비교vWF、TF、FPA급D-이취균승고(P＜0.01)；조잉시여대조조화잉전비교vWF、TF、FPA급D-이취체균승고(P＜0.01)，APTT강저(P＜0.01)。결론항심린지항체양성복발성유산환자잉전즉존재병이성고응상태，임신후저충고응상태진행성가중，정동태변화과정。
Objective To investigate the changes of coagulation in recurrent spontaneous abortion women with anticardiolipin antibody positive. Methods From January 2010 to January 2012, 46 recurrent spontaneous abortion women with positive anticardiolipin antibody were involved in this study. 23 recurrent spontaneous abortion women with negative anticardiolipin antibody and 23 healthy women who have a pregnancy plan were recruited as the controls. Blood samples were drawn for coagulation test at 3 days after the menstruation before pregnancy;the day that first found early pregnancy test was positive and two weeks later. Results In recurrent spontaneous abortion women with anticardiolipin antibody positive the vWF and TF is higher than the controls and before pregnancy. When it is very early pregnancy the vWF, TF, FPA and D-dimer is higher than the controls and before pregnancy. While it is early pregnancy the vWF, TF, FPA and D-due is higher than the controls and before pregnancy. APTT is lower. Conclusion In recurrent spontaneous abortion women with anticardiolipin antibody positive, there is a pathological prothombotic state before pregnancy. This disorder will become more severe and changes step by step when pregnancy.