CAJ | 학술논문

以4-（2-（5-乙基吡啶-2-基）乙氧基）苯甲醛为原料,通过还原、氯化、缩合、溴化、环合五步反应得到亚氨基吡格列酮,总收率57%。此方法原料易得,反应条件温和,操作过程简单,未使用毒性较大的丙烯酸甲酯,产品收率较高,有利于工业化生产。
이4-（2-（5-을기필정-2-기）을양기）분갑철위원료,통과환원、록화、축합、추화、배합오보반응득도아안기필격렬동,총수솔57%。차방법원료역득,반응조건온화,조작과정간단,미사용독성교대적병희산갑지,산품수솔교고,유리우공업화생산。
A novel synthetic method of 5-{4-[2-（5-Ethyl-2-pyridyl）ethoxy]benzyl}-2-imino-4-thiazolidin-one can be got through reduction chloration condensation bromination and cyclization when the 4-[2-（5-Ethyl-pyridin-2-yl）-ethoxy]-benzaldehyde was used as raw material.The total yield was achieved to 57%.Comparing to other ordinary methods.this synthetic route had many advantages,such as cheap raw materials,mild reaction conditions,simple opration,and higher yield,especially high toxic methyl acrylate was not used,so it had broad application prospects in industry production.