医学美学美容（中旬刊）
醫學美學美容（中旬刊）
의학미학미용（중순간）
MEDICAL AESTHETICS AND COSMETOLOGY
2014年
9期
704-705
,共2页
慢性荨麻疹%非索非那定%递减疗
慢性蕁痳疹%非索非那定%遞減療
만성담마진%비색비나정%체감료
chronic urticaria%fexofenadine hydrochloride%descending treatment method
目的：观察非索非那定递减疗法治疗慢性特发性荨麻疹（CIU）的疗效。方法将121例 CIU 患者随机分为两组，治疗组61例和对照组60例。治疗组患者采用非索非那定递减疗法，对照组采用非索非那定每日疗法，疗程均为4周。观察两组治疗效果、停药4周后复发率及不良反应情况。结果治疗2周时，治疗组总有效率为86．9％，高于对照组的63．3％，差异有统计学意义（P ＜0．01）。治疗4周时，治疗组总有效率为91．8％，高于对照组的65．0％，差异有统计学意义（P ＜0．01）。治疗2、4周及停药4周后，症状积分二组均降低，且治疗组低于对照组，差异均有统计学意义（P ＜0．05或 P ＜0．01）。停药4周后治疗组复发率低于对照组，差异有统计学意义（P ＜0．01）。二组均未发生严重不良反应。结论非索非那定递减疗法治疗 CIU 效果比每日疗法更好，复发率更低，安全性良好，值得临床推广应用。
目的：觀察非索非那定遞減療法治療慢性特髮性蕁痳疹（CIU）的療效。方法將121例 CIU 患者隨機分為兩組，治療組61例和對照組60例。治療組患者採用非索非那定遞減療法，對照組採用非索非那定每日療法，療程均為4週。觀察兩組治療效果、停藥4週後複髮率及不良反應情況。結果治療2週時，治療組總有效率為86．9％，高于對照組的63．3％，差異有統計學意義（P ＜0．01）。治療4週時，治療組總有效率為91．8％，高于對照組的65．0％，差異有統計學意義（P ＜0．01）。治療2、4週及停藥4週後，癥狀積分二組均降低，且治療組低于對照組，差異均有統計學意義（P ＜0．05或 P ＜0．01）。停藥4週後治療組複髮率低于對照組，差異有統計學意義（P ＜0．01）。二組均未髮生嚴重不良反應。結論非索非那定遞減療法治療 CIU 效果比每日療法更好，複髮率更低，安全性良好，值得臨床推廣應用。
목적：관찰비색비나정체감요법치료만성특발성담마진（CIU）적료효。방법장121례 CIU 환자수궤분위량조，치료조61례화대조조60례。치료조환자채용비색비나정체감요법，대조조채용비색비나정매일요법，료정균위4주。관찰량조치료효과、정약4주후복발솔급불량반응정황。결과치료2주시，치료조총유효솔위86．9％，고우대조조적63．3％，차이유통계학의의（P ＜0．01）。치료4주시，치료조총유효솔위91．8％，고우대조조적65．0％，차이유통계학의의（P ＜0．01）。치료2、4주급정약4주후，증상적분이조균강저，차치료조저우대조조，차이균유통계학의의（P ＜0．05혹 P ＜0．01）。정약4주후치료조복발솔저우대조조，차이유통계학의의（P ＜0．01）。이조균미발생엄중불량반응。결론비색비나정체감요법치료 CIU 효과비매일요법경호，복발솔경저，안전성량호，치득림상추엄응용。
Objectives To investigate the curative ef ect of fexofenadine hydrochloride for chronic idiopathic urticaria by descending course of treatment and daily treatment method.Meth-ods 121 patients were randomly divided into two groups.Patients in treatment group were prescribed with fexofenadine hydrochloride by descending course,while patients in control group were prescribed with fexofenadine hydrochloride by daily treatment method.The total course of treatment was 4 weeks,respectively.These two groups were evaluated every 2 weeks to observe the cur-ative ef ect or any side ef ects during the course of treatment,and fol owed by a four -week fol ow -up visit.Results After two weeks and four weeks treatment,the ef ective rate of treatment group was 86.9%,91.8%,which was distinctively higher than the control group(63.3%,65.0%),(P <0.01). <br> After two weeks treatment,four weeks treatment and one -month fol ow -up,the symptom score of treatment group was distinctively lower than the control group(P <0.01).Neither of two groups had severe side ef ect.Conclusions The descending treatment method has bet er curative ef ect and lower recurrence rate than daily treatment method,and is worthy of promotion in clinical work.
