医学美学美容（中旬刊）
醫學美學美容（中旬刊）
의학미학미용（중순간）
MEDICAL AESTHETICS AND COSMETOLOGY
2014年
9期
681-682
,共2页
偏头痛%托吡酯%氟桂利嗪
偏頭痛%託吡酯%氟桂利嗪
편두통%탁필지%불계리진
migraine%topiramate%flunarizine
目的：观察两药联用（托吡酯联合氟桂利嗪）预防偏头痛的疗效。方法选择偏头痛患者117例，随机分为托吡酯单药治疗组、托吡酯联合氟桂利嗪组（联合治疗组）和氟桂利嗪单药组3组，每组均为39例患者。治疗周期为6周，观察3组患者治疗前后头痛发作程度、发作频率、持续时间及副作用。结果联合治疗组的总有效率为87．2％，氟桂利嗪组的总有效率为64．1％，托吡酯组的总有效率为59．0％，联合治疗组与单药组比较有明显统计学差异（P ＜0．05），3组患者治疗中副作用无明显差异。结论托吡酯联合氟桂利嗪预防偏头痛疗效更明显。
目的：觀察兩藥聯用（託吡酯聯閤氟桂利嗪）預防偏頭痛的療效。方法選擇偏頭痛患者117例，隨機分為託吡酯單藥治療組、託吡酯聯閤氟桂利嗪組（聯閤治療組）和氟桂利嗪單藥組3組，每組均為39例患者。治療週期為6週，觀察3組患者治療前後頭痛髮作程度、髮作頻率、持續時間及副作用。結果聯閤治療組的總有效率為87．2％，氟桂利嗪組的總有效率為64．1％，託吡酯組的總有效率為59．0％，聯閤治療組與單藥組比較有明顯統計學差異（P ＜0．05），3組患者治療中副作用無明顯差異。結論託吡酯聯閤氟桂利嗪預防偏頭痛療效更明顯。
목적：관찰량약련용（탁필지연합불계리진）예방편두통적료효。방법선택편두통환자117례，수궤분위탁필지단약치료조、탁필지연합불계리진조（연합치료조）화불계리진단약조3조，매조균위39례환자。치료주기위6주，관찰3조환자치료전후두통발작정도、발작빈솔、지속시간급부작용。결과연합치료조적총유효솔위87．2％，불계리진조적총유효솔위64．1％，탁필지조적총유효솔위59．0％，연합치료조여단약조비교유명현통계학차이（P ＜0．05），3조환자치료중부작용무명현차이。결론탁필지연합불계리진예방편두통료효경명현。
Objective To study the ef ects of topiramate and flunarizine in the treatment of migraine.Method 117 patients with migraine were divided into three groups (n =39 each)and were treated with combined topiramate and flunarizine,or with flunarizine or topiramate alone,respectively.The varied degrees of ef icacy and the side ef ects were analysed.Result The total ef-fective rate of the combined therapy group (87.2%)was obviously higher than that in the control groups (64.1% and 59.0%)(P <0.05).The side ef ects showed no dif erences between the three groups.Conclusion Combined topiramate and flunarizine is preferable to the single use of the two drugs for its ef icacy and safety in the treatment of migraine.
