化学与生物工程
化學與生物工程
화학여생물공정
CHEMISTRY & BIOENGINEERING
2014年
9期
39-41
,共3页
去氢表雄酮%醋酸阿比特龙%合成
去氫錶雄酮%醋痠阿比特龍%閤成
거경표웅동%작산아비특룡%합성
dehydroepiandrosterone%abiraterone acetate%synthesis
以去氢表雄酮为原料，经与水合肼缩合、碘代、再与3-吡啶溴化镁发生偶联反应、乙酰化等4步反应合成了目标产物醋酸阿比特龙，总收率为51.4％。产物结构经1 HNMR、元素分析表征。
以去氫錶雄酮為原料，經與水閤肼縮閤、碘代、再與3-吡啶溴化鎂髮生偶聯反應、乙酰化等4步反應閤成瞭目標產物醋痠阿比特龍，總收率為51.4％。產物結構經1 HNMR、元素分析錶徵。
이거경표웅동위원료，경여수합정축합、전대、재여3-필정추화미발생우련반응、을선화등4보반응합성료목표산물작산아비특룡，총수솔위51.4％。산물결구경1 HNMR、원소분석표정。
Abiraterone acetate was synthesized from dehydroepiandrosterone by condensation with hydra-zine,iodization,cross-coupling with 3-pyridylmagnesium bromide and acetylation in turn.The overall yield was 5 1.4%.The structure of the compounds were determined by 1 HNMR and elemental analysis.
