CAJ | 학술논문

目的：比较在二甲双胍基础上加用利拉鲁肽与西格列汀治疗2型糖尿病（ T2DM）对血糖控制的疗效。方法将2012年11月-2014年1月收治的34例 T2DM 患者随机分为西格列汀组16例和利拉鲁肽组18例，西格列汀组给予西格列汀联合二甲双胍治疗，利拉鲁肽组给予利拉鲁肽联合二甲双胍治疗，两组均治疗16周。观察两组治疗前、后体质量指数（BMI）、空腹血糖（FBG）及餐后2 h血糖（2 h PBG）、糖化血红蛋白（HbA1c）变化情况。结果治疗16周后两组 BMI、FBG 及2 h PBG、HbA1c 较治疗前均降低，且利拉鲁肽组 BMI 和 FBG 较西格列汀组明显降低（P<0.05，P<0.01）。两组均无低血糖发生，利拉鲁肽组发生胃肠道反应3例，西格列汀组发生1例，均自行缓解。结论西格列汀或利拉鲁肽联合盐酸二甲双胍均可有效降低糖尿病患者 BMI及血糖，但利拉鲁肽能更加明显的降低FBG及 BMI。
목적：비교재이갑쌍고기출상가용리랍로태여서격렬정치료2형당뇨병（ T2DM）대혈당공제적료효。방법장2012년11월-2014년1월수치적34례 T2DM 환자수궤분위서격렬정조16례화리랍로태조18례，서격렬정조급여서격렬정연합이갑쌍고치료，리랍로태조급여리랍로태연합이갑쌍고치료，량조균치료16주。관찰량조치료전、후체질량지수（BMI）、공복혈당（FBG）급찬후2 h혈당（2 h PBG）、당화혈홍단백（HbA1c）변화정황。결과치료16주후량조 BMI、FBG 급2 h PBG、HbA1c 교치료전균강저，차리랍로태조 BMI 화 FBG 교서격렬정조명현강저（P<0.05，P<0.01）。량조균무저혈당발생，리랍로태조발생위장도반응3례，서격렬정조발생1례，균자행완해。결론서격렬정혹리랍로태연합염산이갑쌍고균가유효강저당뇨병환자 BMI급혈당，단리랍로태능경가명현적강저FBG급 BMI。
Objective To compare the effects of Liraglutide and Sitagliptin respectively combined with Metform-in in treatment of type 2 diabetes mellitus(T2DM). Methods A total of 34 patients with T2DM during November 2012 and January 2014 were randomly divided into Sitagliptin group(n=16)and Liraglutide group(n=18). The Sitagliptin group received Sitagliptin combined with Metformin therapy,while Liraglutide group underwent Liraglutide treatment com-bined with Metformin therapy,and the treatment time was 16 weeks in the two groups. The changes in levels of contrast before and after treatment in patients with body mass index( BMI),fasting plasma glucose( FBG)and postprandial 2 h blood glucose(2 h PBG)and glycosylated hemoglobin(HbA1c)in the two groups before and after treatment were com-pared. Results The levels of BMI,FBG,2 h PBG and HbA1c after treatment for 16 weeks were significantly decreased compared with those before treatment in the two groups,and levels of BMI and FBC in the Liraglutide group were more obviously decreased compared with those in Sitagliptin group(P<0. 05,P<0. 01). No hypoglycemia was found in the two groups. Three patients in Liraglutide group and one patient in Sitagliptin group had gastrointestinal tract reaction,and all the patients were relieved by themselves. Conclusion Liraglutide or Sitagliptin combined with Metformin can effec-tively decrease the levels of BMI and blood glucose,but the Liraglutide combined with Metformin can decrease more sig-nificantly the levels of FBG and BMI in T2DM patients.