浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
17期
1468-1471
,共4页
王诗怡%黄争%范一宏%吕宾
王詩怡%黃爭%範一宏%呂賓
왕시이%황쟁%범일굉%려빈
氢呼气试验%胃排空试验%小肠细菌过度生长%功能性消化不良
氫呼氣試驗%胃排空試驗%小腸細菌過度生長%功能性消化不良
경호기시험%위배공시험%소장세균과도생장%공능성소화불량
Hydrogen breath test%Gastric emptying test%Smal intestinal bacterial overgrowth%Functional dyspepsia
目的：探讨功能性消化不良（functional dyspepsia，FD）患者口盲肠传输时间（oro- cecal transit time，OCTT）和小肠细菌过度生长（smal intestinal bacterialovergrowth，SIBO）及与胃排空延迟的关系。方法41例FD患者与13例健康者行乳果糖氢呼气试验和小钡条法胃排空试验，通过观察呼气氢浓度基础值、产氢高峰的变化曲线测定OCTT及了解有无SIBO；观察胃内钡条排空率确定有无胃排空延迟。结果（1）FD组29例患者行胃排空检查，胃排空延缓占58.6%。对照组胃排空占20.0%；两组比较差异有统计学意义（P＜0.05）；（2）41.5%（17/41）FD患者OCTT结果异常，且其中有29.4%（5/17）的患者合并有SIBO，而对照组无异常；87.8%（36/41）无 SIBO的FD患者OCTT为（110.8±45.0）min，较对照组的（78.3±19.0）min明显延长，差异有统计学意义（P＜0.05）；（3）FD患者OCTT延长与胃排空延迟及SIBO均无相关性。结论 FD患者OCTT时间较对照组明显延长，但与胃排空延迟与SIBO均无相关性，提示小肠动力异常可能是FD的发病的独立原因之一。
目的：探討功能性消化不良（functional dyspepsia，FD）患者口盲腸傳輸時間（oro- cecal transit time，OCTT）和小腸細菌過度生長（smal intestinal bacterialovergrowth，SIBO）及與胃排空延遲的關繫。方法41例FD患者與13例健康者行乳果糖氫呼氣試驗和小鋇條法胃排空試驗，通過觀察呼氣氫濃度基礎值、產氫高峰的變化麯線測定OCTT及瞭解有無SIBO；觀察胃內鋇條排空率確定有無胃排空延遲。結果（1）FD組29例患者行胃排空檢查，胃排空延緩佔58.6%。對照組胃排空佔20.0%；兩組比較差異有統計學意義（P＜0.05）；（2）41.5%（17/41）FD患者OCTT結果異常，且其中有29.4%（5/17）的患者閤併有SIBO，而對照組無異常；87.8%（36/41）無 SIBO的FD患者OCTT為（110.8±45.0）min，較對照組的（78.3±19.0）min明顯延長，差異有統計學意義（P＜0.05）；（3）FD患者OCTT延長與胃排空延遲及SIBO均無相關性。結論 FD患者OCTT時間較對照組明顯延長，但與胃排空延遲與SIBO均無相關性，提示小腸動力異常可能是FD的髮病的獨立原因之一。
목적：탐토공능성소화불량（functional dyspepsia，FD）환자구맹장전수시간（oro- cecal transit time，OCTT）화소장세균과도생장（smal intestinal bacterialovergrowth，SIBO）급여위배공연지적관계。방법41례FD환자여13례건강자행유과당경호기시험화소패조법위배공시험，통과관찰호기경농도기출치、산경고봉적변화곡선측정OCTT급료해유무SIBO；관찰위내패조배공솔학정유무위배공연지。결과（1）FD조29례환자행위배공검사，위배공연완점58.6%。대조조위배공점20.0%；량조비교차이유통계학의의（P＜0.05）；（2）41.5%（17/41）FD환자OCTT결과이상，차기중유29.4%（5/17）적환자합병유SIBO，이대조조무이상；87.8%（36/41）무 SIBO적FD환자OCTT위（110.8±45.0）min，교대조조적（78.3±19.0）min명현연장，차이유통계학의의（P＜0.05）；（3）FD환자OCTT연장여위배공연지급SIBO균무상관성。결론 FD환자OCTT시간교대조조명현연장，단여위배공연지여SIBO균무상관성，제시소장동력이상가능시FD적발병적독립원인지일。
Objective To investigate the relationship between oro- cecal transit time (OCTT) and smal intestinal bacterial overgrowth (SIBO) in functional dyspepsia (FD) patients. Methods 41 patients with FD and 13 healthy subjects were enrol ed in the study. The OCTT was determined by hydrogen breath test,gastric emptying test was performed with smal barium strip method. The baseline value of hydrogen and change curve of hydrogen peak were used to analyze whether the SIBO was pre-sent;and gastric emptying rate was used to judge the existence of delayed gastric emptying. Results 29 FD patients underwent gastric emptying test,the rate of delayed gastric emptying in FD patients was higher than that in controls (58.6%vs.20.0%, P<0.05). Abnormal OCTT was detected in 17 FD patients(41.5%),among whom 5 were complicated with SIBO (29.4%);while there was no abnormality OCTT detected in control group. OCTT in 36 FD patients without SIBO was significant longer than that in con-trols (110.8±45.0min vs. 78.3±19.0 min, P<0.05). The extension of OCTT in FD patients had no correlation with delayed gastric emptying and SIBO. Conclusion The results suggest that intestinal motility disorders may be one of the independent causative factors for development of functional dyspepsia.
