CAJ | 학술논문

目的：探讨子痫前期治疗前后血浆N氨基末端脑利钠肽前体（NT-proBNP）和炎性细胞因子水平的变化。方法以荧光免疫分析、放射免疫分析和超敏酶免疫分析法分别测定了93例子痫患者（其中45例轻度和48例重度）血浆中NT-proBNP、IL-6、hs-CRP和TNF-α水平，并与42例正常对照组进行对比分析。结果93例子痫患者治疗前血浆NT-proBNP、IL-6、hs-CRP和TNF-α水平较42例正常对照组明显增高（P均＜0．01），并随子痫前期的严重程度而增加。治疗后45例轻度子痫前期患者血浆NT-proBNP、IL-6、hs-CRP和TNF-α水平恢复至正常，48例重度子痫前期患者除血浆中IL-6恢复至正常水平外（P＞0．05），血浆NT-proBNP、hs-CRP和TNF-α水平明显降低，但较正常对照组仍增高（P 均＜0．05）。结论血浆NT-proBNP和炎性细胞因子参与子痫前期发生、发展的病理生理过程，是考核子痫前期治疗的有效指标。
목적：탐토자간전기치료전후혈장N안기말단뇌리납태전체（NT-proBNP）화염성세포인자수평적변화。방법이형광면역분석、방사면역분석화초민매면역분석법분별측정료93례자간환자（기중45례경도화48례중도）혈장중NT-proBNP、IL-6、hs-CRP화TNF-α수평，병여42례정상대조조진행대비분석。결과93례자간환자치료전혈장NT-proBNP、IL-6、hs-CRP화TNF-α수평교42례정상대조조명현증고（P균＜0．01），병수자간전기적엄중정도이증가。치료후45례경도자간전기환자혈장NT-proBNP、IL-6、hs-CRP화TNF-α수평회복지정상，48례중도자간전기환자제혈장중IL-6회복지정상수평외（P＞0．05），혈장NT-proBNP、hs-CRP화TNF-α수평명현강저，단교정상대조조잉증고（P 균＜0．05）。결론혈장NT-proBNP화염성세포인자삼여자간전기발생、발전적병리생리과정，시고핵자간전기치료적유효지표。
Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP(with fluore-scent immunoassay)and infammatory cytokines(IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay)in plasma were detected in 93 patients with preeclamp-sia (including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia),and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines (IL-6 ,hs-CRP and TNF-α)levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people (P<0 .0 1 ).The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level (P>0 .05 ).Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people (P<0 .05 ).Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.