CAJ | 학술논문

目的：通过观察Ki-67在弥漫大B细胞淋巴瘤（DLBCL）与淋巴结反应性增生中以及在生发中心B细胞（GCB）型和非GCB型（non-GCB）中的表达差异，探讨Ki-67的临床意义。方法将60例DLBCL标本设为观察组，将20例淋巴结反应性增生组织标本设为对照组。比较Ki-67在GCB型和non-GCB型中的表达差异，并分析Ki-67与DLBCL分型、国际预后指数（IPI）、近期疗效、预后的关系。结果 Ki-67在观察组和对照组的平均表达率分别为（69．17±14．73）％和（40．50±14．95）％，差异有统计学意义（t＝7．509，P＜0．0001）。Ki-67在GCB型和non-GCB中的平均表达率分别为（59．29±14．92）％和（71．96±13．39）％，有显著差异（t＝3．019，P＝0．0038）。Ki-67在IPI＜2组和IPI≥2组中的平均表达率分别为（65．29±15．17）％和（74．23±12．70）％，差别有统计学意义（t＝2．422，P＝0．0186）。结论 Ki-67的异常表达与DLBCL的临床分期、IPI指数、分型、近期疗效及预后等相关，对判断疗效和预后具有重要临床价值。
목적：통과관찰Ki-67재미만대B세포림파류（DLBCL）여림파결반응성증생중이급재생발중심B세포（GCB）형화비GCB형（non-GCB）중적표체차이，탐토Ki-67적림상의의。방법장60례DLBCL표본설위관찰조，장20례림파결반응성증생조직표본설위대조조。비교Ki-67재GCB형화non-GCB형중적표체차이，병분석Ki-67여DLBCL분형、국제예후지수（IPI）、근기료효、예후적관계。결과 Ki-67재관찰조화대조조적평균표체솔분별위（69．17±14．73）％화（40．50±14．95）％，차이유통계학의의（t＝7．509，P＜0．0001）。Ki-67재GCB형화non-GCB중적평균표체솔분별위（59．29±14．92）％화（71．96±13．39）％，유현저차이（t＝3．019，P＝0．0038）。Ki-67재IPI＜2조화IPI≥2조중적평균표체솔분별위（65．29±15．17）％화（74．23±12．70）％，차별유통계학의의（t＝2．422，P＝0．0186）。결론 Ki-67적이상표체여DLBCL적림상분기、IPI지수、분형、근기료효급예후등상관，대판단료효화예후구유중요림상개치。
Objective To investigate the different expressions of Ki-67 between diffuse large B cell lymphoma (DLBCL)and the reactive hyperplasia of lymphnode (RH),germinal center B cells (GCB)and non-GCB types,and to explore the clinical significance of Ki-67.Methods Samples from 60 DLBCL patients served as observation group,while the other 20 tissue samples from patients with lymphoid reactive hyperplasia as control group.The difference of Ki-67 expres-sions between GCB and non-GCB were compared and the relationships between Ki-67 expression and DLBCL,the international prognostic index (IPI),short-term efficacy and prognosis were analyzed. Results The average expression rate of Ki-67 was (69.17±14.73)%and (40.50±14.95)% in observation and control groups respectively ,and the difference was significant (t= 7 .5 0 9 ,P<0.0001),and it was (59.29±14.92)%and (71.96±13.39)%in GCB and non-GCB groups (t= 3.019,P= 0.0038)and (65.29±15.17)% and (74.23±12.70)% in IPI<2 and IPI≥2 groups (t= 2.422,P= 0.0186),respectively.Conclusion The abnormal expression of Ki-67 is closely associated with clinical stages,index of IPI,types,short-term effect and prognosis in DLB-CL,which plays an important role in the diagnosis,treatment and prognosis of DLBCL.