CAJ | 학술논문

目的：探讨血清脂蛋白和超敏C反应蛋白（hs-CRP）水平的变化对2型糖尿病肾病患者的临床意义。方法根据尿白蛋白排泄率（UAER）将174例2型糖尿病患者分为糖尿病无肾病组74例、早期糖尿病肾病组52例、临床糖尿病肾病组48例，以健康体检者60例为对照组，检测各组患者脂蛋白（α）[Lp（α）]、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及hs-CRP水平，并分析其血清水平变化与UAER的相关性。结果糖尿病患者各组Lp（α）、hs-CRP水平均高于对照组，且糖尿病患者各组间Lp（α）、hs-CRP水平随着UAER增加而升高，差异有统计学意义（P＜0．05）；糖尿病患者各组HDL-C、LDL-C水平的比较无统计学意义（P＞0．05）；Lp（α）、hs-CRP分别与UAER呈显著正相关（r＝0．8069，0．8989）。结论 Lp （α）、hs-CRP水平与2型糖尿病肾病的发生、发展密切相关，Lp（α）和hs-CRP的检测对2型糖尿病肾病的早期诊断和预后评价具有重要的临床意义。
목적：탐토혈청지단백화초민C반응단백（hs-CRP）수평적변화대2형당뇨병신병환자적림상의의。방법근거뇨백단백배설솔（UAER）장174례2형당뇨병환자분위당뇨병무신병조74례、조기당뇨병신병조52례、림상당뇨병신병조48례，이건강체검자60례위대조조，검측각조환자지단백（α）[Lp（α）]、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）이급hs-CRP수평，병분석기혈청수평변화여UAER적상관성。결과당뇨병환자각조Lp（α）、hs-CRP수평균고우대조조，차당뇨병환자각조간Lp（α）、hs-CRP수평수착UAER증가이승고，차이유통계학의의（P＜0．05）；당뇨병환자각조HDL-C、LDL-C수평적비교무통계학의의（P＞0．05）；Lp（α）、hs-CRP분별여UAER정현저정상관（r＝0．8069，0．8989）。결론 Lp （α）、hs-CRP수평여2형당뇨병신병적발생、발전밀절상관，Lp（α）화hs-CRP적검측대2형당뇨병신병적조기진단화예후평개구유중요적림상의의。
Obj ective To explore the significance of serum lipoprotein and high sensitivity C-reactive protein (hs-CRP)level for the patients with type 2 diabetic nephropathy.Methods 174 patients with type 2 diabetic mellitus were divided into diabetic mellitus group,early diabetic nephropathy group and clinical diabetic nephropathy group,according to the urinary albumin excre-tion rate (UAER).60 healthy individuals were chosen as control group.Lipoprotein (α)[Lp(α)], high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C)and hs-CRP were detected,and the results were analyzed statistically.Results The level of Lp (α), hs-CRP were significantly higher in patients with diabetic mellitus than those in control group (P<0.05).Among the three groups with diabetic mellitus,the level of Lp(α)and hs-CRP got progres-sively significant higher with the increase of UAER (P<0 .05 )whereas the level of HDL-C and LDL-C did not find significant difference(P>0 .05 ).There were linear positive correlation between Lp(α),hs-CRP and UAER levels(r= 0.8069,0.8989).Conclusion Lp(α),hs-CRP levels may be related to the progression of diabetic nephropathy,and their detection had important clinical sig-nificance in early diagnosis and prognostic evaluation of type 2 diabetic nephropathy.