实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
17期
8-11
,共4页
肺源性心脏病%心力衰竭%低分子肝素钙%血液流变学%N-末端脑钠肽前体%D-二聚体%血栓
肺源性心髒病%心力衰竭%低分子肝素鈣%血液流變學%N-末耑腦鈉肽前體%D-二聚體%血栓
폐원성심장병%심력쇠갈%저분자간소개%혈액류변학%N-말단뇌납태전체%D-이취체%혈전
pulmonary heart disease%heart failure%low molecular heparin calcium%hemorheology%N-terminal pro-brain natriuretic peptide%blood plasma D-dipolymey%thrombus
目的：观察低分子肝素钙对肺源性心脏病（肺心病）心力衰竭患者血液流变学、血浆N-末端脑钠肽前体（NT-proBNP）及D-二聚体（D-D）水平的影响。方法选取2011年1月-2014年1月肺心病心力衰竭患者95例，随机分为观察组45例及对照组50例。2组均给予常规治疗，观察组在此基础上加用低分子肝素钙皮下注射。观察2组临床疗效、不良反应、治疗前后血液流变学、血浆NT-proBNP及D-D水平的变化。结果治观察总有效率95．56％，显著高于对照组总有效率82．00％（P＜0．05），2组不良反应无显著差异（P＞0．05）；2组治疗后血液流变学、血浆NT-proBNP及D-D水平均较治疗前显著改善（P＜0．05或P＜0．01）；观察组显著优于对照组（P＜0．05或P＜0．01）。结论低分子肝素钙联合多巴酚丁胺和硫酸镁治疗肺心病心力衰竭患者安全有效，可显著改善患者血液流变学指标，降低血浆NT-proBNP及D-D水平。
目的：觀察低分子肝素鈣對肺源性心髒病（肺心病）心力衰竭患者血液流變學、血漿N-末耑腦鈉肽前體（NT-proBNP）及D-二聚體（D-D）水平的影響。方法選取2011年1月-2014年1月肺心病心力衰竭患者95例，隨機分為觀察組45例及對照組50例。2組均給予常規治療，觀察組在此基礎上加用低分子肝素鈣皮下註射。觀察2組臨床療效、不良反應、治療前後血液流變學、血漿NT-proBNP及D-D水平的變化。結果治觀察總有效率95．56％，顯著高于對照組總有效率82．00％（P＜0．05），2組不良反應無顯著差異（P＞0．05）；2組治療後血液流變學、血漿NT-proBNP及D-D水平均較治療前顯著改善（P＜0．05或P＜0．01）；觀察組顯著優于對照組（P＜0．05或P＜0．01）。結論低分子肝素鈣聯閤多巴酚丁胺和硫痠鎂治療肺心病心力衰竭患者安全有效，可顯著改善患者血液流變學指標，降低血漿NT-proBNP及D-D水平。
목적：관찰저분자간소개대폐원성심장병（폐심병）심력쇠갈환자혈액류변학、혈장N-말단뇌납태전체（NT-proBNP）급D-이취체（D-D）수평적영향。방법선취2011년1월-2014년1월폐심병심력쇠갈환자95례，수궤분위관찰조45례급대조조50례。2조균급여상규치료，관찰조재차기출상가용저분자간소개피하주사。관찰2조림상료효、불량반응、치료전후혈액류변학、혈장NT-proBNP급D-D수평적변화。결과치관찰총유효솔95．56％，현저고우대조조총유효솔82．00％（P＜0．05），2조불량반응무현저차이（P＞0．05）；2조치료후혈액류변학、혈장NT-proBNP급D-D수평균교치료전현저개선（P＜0．05혹P＜0．01）；관찰조현저우우대조조（P＜0．05혹P＜0．01）。결론저분자간소개연합다파분정알화류산미치료폐심병심력쇠갈환자안전유효，가현저개선환자혈액류변학지표，강저혈장NT-proBNP급D-D수평。
Obj ective To observe the clinical effects of low molecular heparin calcium on hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.Methods 95 heart failure patients with pulmonary heart disease were randomly divided into observation (n= 45 )and control groups (n= 50),both treated with regular treatment.Extra hypodermic injection of low molecular heparin calcium was given to observation group.Clinical effects,adverse events,hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipolymer (D-D)level were observed.Results Effective rate in observation group (95 .56%)was significantly higher than in control group (82.00%)(P<0.05),and significant difference was found in adverse events. Hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level were improved in both groups after treatment (P<0.05,P<0.01),and differ-ences between 2 groups were significant (P<0.05,P<0.01).Conclusion Low molecular hep-arin calcium combined with dobutamine and magnesium sulfate has the potential to improve the hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.
