CAJ | 학술논문

目的：探讨丹红注射液对大鼠急性脑梗死后脑组织的保护作用。方法制作大鼠急性大脑中动脉栓塞模型30例，随机分为假手术组、手术组，手术＋丹红组，各10例，连续5 d后测定脑组织匀浆超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活力和丙二醛（MDA）含量，同时进行神经功能评分、脑含水量测定和病理组织学检查。结果丹红组＋手术组大鼠脑组织的SOD和GSH-Px活力较手术组显著增高，MDA含量降低，差异有统计学意义（P＜0．01），且脑组织病理改变也较轻。结论丹红注射液具有保护脑组织损伤的作用，可能与增强缺血脑组织SOD和GSH-Px活力，降低MDA含量有关。
목적：탐토단홍주사액대대서급성뇌경사후뇌조직적보호작용。방법제작대서급성대뇌중동맥전새모형30례，수궤분위가수술조、수술조，수술＋단홍조，각10례，련속5 d후측정뇌조직균장초양화물기화매（SOD）、곡광감태과양화물매（GSH-Px）활력화병이철（MDA）함량，동시진행신경공능평분、뇌함수량측정화병리조직학검사。결과단홍조＋수술조대서뇌조직적SOD화GSH-Px활력교수술조현저증고，MDA함량강저，차이유통계학의의（P＜0．01），차뇌조직병리개변야교경。결론단홍주사액구유보호뇌조직손상적작용，가능여증강결혈뇌조직SOD화GSH-Px활력，강저MDA함량유관。
Obj ective To investigate the brain-protective mechanism of Danhong inj ection in rats with acute cerebral infarction.Methods 30 rats of acute cerebral infarction models was es-tablished by means of occlusion of middle cerebral artery and randomly divided into Sham-operation group,operation group and operation plus Danhong group,10 cases in each group.The superoxide dismutase (SOD),glutathion peroxidase (GSH-Px)activities and the malondiadehyde (MDA) content in the cerebral tissue were determined after 5 d.Meanwhile the neurological function,Brain water content and histopathologic examination were observed.Results The SOD and GSH-Px activities in the operation plus Danhong group increased obviously,while the MDA content de-creased significantly compared with the operation group (P<0 .0 1 ).Moreover,there were slighter pathological changes in brain tissues.Conclusion Danhong inj ection has a certain protective effects on damage of brain tissues,which is possibly related to increased SOD and GSH-Px activities,and decreased MDA content.