中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
18期
3270-3273
,共4页
宋新建%卢红建%马丹%王兴山%沈晓明
宋新建%盧紅建%馬丹%王興山%瀋曉明
송신건%로홍건%마단%왕흥산%침효명
卒中%瘦素%颈动脉疾病
卒中%瘦素%頸動脈疾病
졸중%수소%경동맥질병
Stroke%Leptin%Carotid artery diseases
目的:探讨急性缺血性脑卒中患者血清瘦素水平与颈动脉粥样硬化(CAS)的关系。方法选择急性缺血性脑卒中患者476例,根据颈动脉彩色超声结果分为CAS组322例和非CAS组154例。CAS组根据CAS的严重程度分为:轻度CAS 161例、中度CAS 114例和重度CAS 47例;根据超声检查分为:硬斑块127例、软斑块65例和混合斑块130例。分析组间血清瘦素水平与颈动脉斑块严重程度、斑块性质的相关性。结果 CAS组血清瘦素水平明显高于非CAS组,差异有统计学意义(P<0.05)。Logistic 回归分析,血清瘦素水平升高是 CAS 形成的独立危险因素。中度和重度CAS患者血清瘦素水平明显高于轻度CAS患者(P<0.01)。Spearman等级相关分析,CAS严重程度与血清瘦素水平呈正相关(r=0.366,P<0.01)。结论血清瘦素水平的升高能预测 CAS的发生,并能评估CAS的严重程度,但尚不能作为评估CAS斑块稳定性的可靠指标。
目的:探討急性缺血性腦卒中患者血清瘦素水平與頸動脈粥樣硬化(CAS)的關繫。方法選擇急性缺血性腦卒中患者476例,根據頸動脈綵色超聲結果分為CAS組322例和非CAS組154例。CAS組根據CAS的嚴重程度分為:輕度CAS 161例、中度CAS 114例和重度CAS 47例;根據超聲檢查分為:硬斑塊127例、軟斑塊65例和混閤斑塊130例。分析組間血清瘦素水平與頸動脈斑塊嚴重程度、斑塊性質的相關性。結果 CAS組血清瘦素水平明顯高于非CAS組,差異有統計學意義(P<0.05)。Logistic 迴歸分析,血清瘦素水平升高是 CAS 形成的獨立危險因素。中度和重度CAS患者血清瘦素水平明顯高于輕度CAS患者(P<0.01)。Spearman等級相關分析,CAS嚴重程度與血清瘦素水平呈正相關(r=0.366,P<0.01)。結論血清瘦素水平的升高能預測 CAS的髮生,併能評估CAS的嚴重程度,但尚不能作為評估CAS斑塊穩定性的可靠指標。
목적:탐토급성결혈성뇌졸중환자혈청수소수평여경동맥죽양경화(CAS)적관계。방법선택급성결혈성뇌졸중환자476례,근거경동맥채색초성결과분위CAS조322례화비CAS조154례。CAS조근거CAS적엄중정도분위:경도CAS 161례、중도CAS 114례화중도CAS 47례;근거초성검사분위:경반괴127례、연반괴65례화혼합반괴130례。분석조간혈청수소수평여경동맥반괴엄중정도、반괴성질적상관성。결과 CAS조혈청수소수평명현고우비CAS조,차이유통계학의의(P<0.05)。Logistic 회귀분석,혈청수소수평승고시 CAS 형성적독립위험인소。중도화중도CAS환자혈청수소수평명현고우경도CAS환자(P<0.01)。Spearman등급상관분석,CAS엄중정도여혈청수소수평정정상관(r=0.366,P<0.01)。결론혈청수소수평적승고능예측 CAS적발생,병능평고CAS적엄중정도,단상불능작위평고CAS반괴은정성적가고지표。
Objective To investigate the relationship between the serum level of leptin and carotid atherosclerosis(CAS) in patients with ischemic stroke. Methods 476 acute ischemic stroke patients were divided into CAS group (n=322) and non-CAS group (n=154) according to carotid color ultrasonographic findings. Patients in CAS group were further divided into mild CAS group (n=161), moderate CAS group (n=114), severe CAS group (n=47) according to the severity of CAS, and into hard plaque group (n=127), soft plaque group (n=65), mixed plaque group (n=130) according to the findings of ultrasonography. Relation of serum level of leptin with severity of CAS and nature of plaque were analyzed. Results The serum leptin level was significantly higher in CAS group than in non-CAS group (P<0.05). Logistical regression analysis showed that elevated serum leptin level was an independent predictor for CAS. The serum leptin level was significantly higher in moderate CAS group and severe CAS than in mild CAS group (P<0.01). Spearman rank correlation analysis revealed that the severity of CAS was positively related with the serum leptin level (r=0.366, P<0.01). Conclusion Elevated serum leptin level can predict the occurrence of CAS and assess its severity, but is not a reliable indicator for the stability of carotid artery plaques.