CAJ | 학술논문

目的：构建一种新型生物可降解雷帕霉素药物洗脱输尿管支架并评估其机械性能及药物释放特性。方法采用聚乳酸为原料，将其溶于氯仿后加入雷帕霉素粉末，通过溶液挥发法构建螺旋形生物可降解雷帕霉素药物洗脱输尿管支架。通过万能压力机检测新型生物可降解雷帕霉素输尿管支架力学性能，并分别在3周、6周、9周和12周时通过色谱分析仪评估其药物释放特性。结果成功构建的生物可降解雷帕霉素药物洗脱输尿管支架，长度为50 mm，内径为0.8 mm，外径1.4 mm，厚度为200μm，带宽为1 mm。支架不仅具有良好的力学性能，并可有效持续释放药物，支架平均雷帕霉素含量为2755μg，3周后支架平均含药量为2670μg，6周后支架平均含药量为2533μg，9周后支架平均含药量为1541μg，12周后支架平均含药量为744μg。结论构建的生物可降解雷帕霉素药物洗脱输尿管支架具有良好的机械性能，可有效释放药物，有望为输尿管损伤或狭窄的治疗提供一种新的简单有效的材料和方法。
목적：구건일충신형생물가강해뢰파매소약물세탈수뇨관지가병평고기궤계성능급약물석방특성。방법채용취유산위원료，장기용우록방후가입뢰파매소분말，통과용액휘발법구건라선형생물가강해뢰파매소약물세탈수뇨관지가。통과만능압력궤검측신형생물가강해뢰파매소수뇨관지가역학성능，병분별재3주、6주、9주화12주시통과색보분석의평고기약물석방특성。결과성공구건적생물가강해뢰파매소약물세탈수뇨관지가，장도위50 mm，내경위0.8 mm，외경1.4 mm，후도위200μm，대관위1 mm。지가불부구유량호적역학성능，병가유효지속석방약물，지가평균뢰파매소함량위2755μg，3주후지가평균함약량위2670μg，6주후지가평균함약량위2533μg，9주후지가평균함약량위1541μg，12주후지가평균함약량위744μg。결론구건적생물가강해뢰파매소약물세탈수뇨관지가구유량호적궤계성능，가유효석방약물，유망위수뇨관손상혹협착적치료제공일충신적간단유효적재료화방법。
Objective To construct a new biodegradable rapamycin-eluting ureteral stent and to evaluate its mechanical property and drug-eluting characteristics. Methods Polylactic was selected as the stent material and dis-solved by chloroform. The rapamycin powder was added into the solution. Then, a new helical biodegradable rapa-mycin-eluting ureteral stent was made by volatilization method. The mechanical property of the stent was measured by universal tension tester, while the drug-eluting characteristic was evaluated by chromatographic analysis ma-chine. Results The new biodegradable rapamycin-eluting ureteral stent had good mechanical property with length in 50 mm, inner diameter in 8 mm, outer diameter in 1.4 mm, thickness in 200μm and width in 1 mm. The stent can continuously release drug. The mean amount of rapamycin of the stent was 2 755 μg. After 3 weeks, the remained mean amount of rapamycin was 2 670μg. At 6 weeks, it was 2 533μg and 1 541 at 9 weeks. Eventually, it was de-creased to 744μg at 12 weeks. Conclusion The new biodegradable rapamycin-eluting ureteral stent made of polylac-tic acid not only has good mechanical property, but also can release drug efficiently, which may provide a new materi-al for the treatment of ureteral strictures.