中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
21期
3240-3241
,共2页
呼吸道感染%革兰阴性菌%胸腺提取物%比阿培南%治疗结果
呼吸道感染%革蘭陰性菌%胸腺提取物%比阿培南%治療結果
호흡도감염%혁란음성균%흉선제취물%비아배남%치료결과
Respiratory tract infections%Gram-negative bacteria%Thymus extracts%Biapenem%Treatment outcome
目的 探讨胸腺肽联合比阿培南治疗革兰阴性杆菌重症下呼吸道感染的疗效和安全性.方法 将54例革兰阴性杆菌重症下呼吸道感染患者随机分为胸腺肽联合比阿培南治疗组26例(A组)和比阿培南治疗组28例(B组),疗程均为7～14d.比较两组临床疗效、比阿培南使用时间、细菌清除率及不良反应情况.结果 A、B两组的临床有效率分别为84.6％、82.1％,差异无统计学意义(P＞0.05)；A组治疗时间(8.2±3.4)d,优于B组的(13.2±3.6)d(P＜0.05)；A、B两组细菌清除率86.7％、80.7％ (P ＞0.05).结论 胸腺肽联合比阿培南治疗革兰阴性杆菌重症下呼吸道感染比阿培南单用治疗时间短,且安全,有效,值得临床推广.
目的 探討胸腺肽聯閤比阿培南治療革蘭陰性桿菌重癥下呼吸道感染的療效和安全性.方法 將54例革蘭陰性桿菌重癥下呼吸道感染患者隨機分為胸腺肽聯閤比阿培南治療組26例(A組)和比阿培南治療組28例(B組),療程均為7～14d.比較兩組臨床療效、比阿培南使用時間、細菌清除率及不良反應情況.結果 A、B兩組的臨床有效率分彆為84.6％、82.1％,差異無統計學意義(P＞0.05)；A組治療時間(8.2±3.4)d,優于B組的(13.2±3.6)d(P＜0.05)；A、B兩組細菌清除率86.7％、80.7％ (P ＞0.05).結論 胸腺肽聯閤比阿培南治療革蘭陰性桿菌重癥下呼吸道感染比阿培南單用治療時間短,且安全,有效,值得臨床推廣.
목적 탐토흉선태연합비아배남치료혁란음성간균중증하호흡도감염적료효화안전성.방법 장54례혁란음성간균중증하호흡도감염환자수궤분위흉선태연합비아배남치료조26례(A조)화비아배남치료조28례(B조),료정균위7～14d.비교량조림상료효、비아배남사용시간、세균청제솔급불량반응정황.결과 A、B량조적림상유효솔분별위84.6％、82.1％,차이무통계학의의(P＞0.05)；A조치료시간(8.2±3.4)d,우우B조적(13.2±3.6)d(P＜0.05)；A、B량조세균청제솔86.7％、80.7％ (P ＞0.05).결론 흉선태연합비아배남치료혁란음성간균중증하호흡도감염비아배남단용치료시간단,차안전,유효,치득림상추엄.
Objective To evaluate the effect and safety of thymosin combined with biapenem in the treatment of severe lower respiratory tract infection of gram negative bacilli.Methods 54 patients with severe lower respiratory tract infection of gram negative bacilli were randomly divided into study group (group A) and control group (group B),group A was treated with thymosin and biapenem,group B biapenem.All patients were treated for 7 ～ 14 days in a course.The clinical effect,treatment time of biapenem,the bacterial clearance rate and adverse drug reaction betweeen two groups were compared.Results The clinical effective rate of group A and B were 84.6％ and 82.1％,respectively,there was no statistical difference (P ＞ 0.05).Treatment time of biapenem in group A and B was (8.2 ±3.4) days and (13.2 ± 3.6) days,respectively,there was statistical difference (P ＜ 0.05).The bacterial clearance rate of group A and B were 86.7％ and 80.7％,respectively,there was no statistical difference between two groups (P ＞ 0.05).Conclusion The treatment time of thymosin combined with biapenem treatment of gram-negative bacilli severe respiratory tract infection was shorter than that of biapenem alone treatment,and it was safe,effective,and worthy of ciinical application.
