CAJ | 학술논문

目的：分析血清胱抑素C（Cys C）联合尿微量清蛋白（mALB）检测在高血压早期肾功能损害中的诊断价值。方法选择2012年1月至2013年12月南京市中西医结合医院320例患者为研究对象，其中高血压组130例，肾功能损害组90例，健康对照组100例。检测每组mALB、肌酐（Scr）、尿素氮（BUN）、Cys C水平，并比较每组Scr、BUN及mALB联合Cys C检测对早期肾功能损害的检出率。结果高血压组mALB、Cys C水平，肾功能损害组mALB、Scr、BUN、Cys C水平均明显高于健康对照组，差异均有统计学意义（P＜0．05）。高血压组Scr、BUN对早期肾功能损害检出率为13．8％、14．6％，均明显低于 mALB联合Cys C （32．3％），差异均有统计学意（P＜0．05）；肾功能损害组 Scr、BUN 对早期肾功能损害检出率均为53．3％，mALB 联合 Cys C 检出率则为100．0％，差异均有统计学意（P＜0．05）。结论 Cys C联合mALB检测可显著提高高血压早期肾功能损害的检出率，值得临床推广应用。
목적：분석혈청광억소C（Cys C）연합뇨미량청단백（mALB）검측재고혈압조기신공능손해중적진단개치。방법선택2012년1월지2013년12월남경시중서의결합의원320례환자위연구대상，기중고혈압조130례，신공능손해조90례，건강대조조100례。검측매조mALB、기항（Scr）、뇨소담（BUN）、Cys C수평，병비교매조Scr、BUN급mALB연합Cys C검측대조기신공능손해적검출솔。결과고혈압조mALB、Cys C수평，신공능손해조mALB、Scr、BUN、Cys C수평균명현고우건강대조조，차이균유통계학의의（P＜0．05）。고혈압조Scr、BUN대조기신공능손해검출솔위13．8％、14．6％，균명현저우 mALB연합Cys C （32．3％），차이균유통계학의（P＜0．05）；신공능손해조 Scr、BUN 대조기신공능손해검출솔균위53．3％，mALB 연합 Cys C 검출솔칙위100．0％，차이균유통계학의（P＜0．05）。결론 Cys C연합mALB검측가현저제고고혈압조기신공능손해적검출솔，치득림상추엄응용。
Objective To analyze the clinical effect of serum cystatin C (Cys C)and micro-albuminuria(mALB) in early renal function injury patients caused by hypertension .Methods One hundred and thirty patients in hyperten-sion group ,90 patients in renal function injury group ,and 100 healthy people in health group were recruited in this study .The level of mALB ,Scr ,BUN ,Cys C were detected .The detection rate of early renal function injury in the three groups were compared .Results The level of mALB ,Cys C in the hypertension group ,the level of mALB ,Scr , BUN ,Cys C in the renal function injury group were significant higher than those indicators in the control group .The detection rates of Scr ,BUN for early renal function injury in the hypertension group were 13 .8% ,14 .6% respective-ly ,which were significantly lower than the rate 32 .3% of united detection mALB and Cys C .In the renal function in-jury group ,the detection rate of Scr ,BUN for the early renal function injury were 53 .3% ,53 .3% respectively ,while the rate of the united mALB and Cys C was 100 .0% ,the differences were statistically significant (P<0 .05) .Conclu-sion United detection of mALB and Cys C could significantly improve the detection rate for early renal function inju-ry .