CAJ | 학술논문

目的：回顾性分析42例肺部真菌感染患者特征和预防性用药的作用。方法选择四平市中心医院重症监护室（IC U ）2012年6月至2013年6月肺部疾病重症患者42例作为研究对象。预防组22例患者在真菌感染不良症状出现前预防性给药；对照组20例患者在发现真菌感染，确诊感染菌种后再对症给予抗菌药物。对比两组患者临床治疗效果和真菌感染特点。结果预防组肺部真菌感染发生率为54．5％，远远低于对照组的95．0％，差异具有统计学意义（ P＜0．01）。在31例IC U受试患者中，肺部真菌感染的病原菌以白假丝酵母菌检出比例最高，为83．9％，明显高于光滑假丝酵母菌的9．7％和近平滑念珠菌的6．5％。结论预防性给药能提高IC U患者肺部真菌感染的治疗效果，但需合理用药，根据疾病特征选择用药类型。
목적：회고성분석42례폐부진균감염환자특정화예방성용약적작용。방법선택사평시중심의원중증감호실（IC U ）2012년6월지2013년6월폐부질병중증환자42례작위연구대상。예방조22례환자재진균감염불량증상출현전예방성급약；대조조20례환자재발현진균감염，학진감염균충후재대증급여항균약물。대비량조환자림상치료효과화진균감염특점。결과예방조폐부진균감염발생솔위54．5％，원원저우대조조적95．0％，차이구유통계학의의（ P＜0．01）。재31례IC U수시환자중，폐부진균감염적병원균이백가사효모균검출비례최고，위83．9％，명현고우광활가사효모균적9．7％화근평활념주균적6．5％。결론예방성급약능제고IC U환자폐부진균감염적치료효과，단수합리용약，근거질병특정선택용약류형。
Objective To analyze retrospectively the effect of of antibacterial drugs prophylaxis on 42 patients with pulmonary fungal infection .Methods Forty two patients with pulmonary fungal infection from June in 2012 to June in 2013 were divided into study group(22 patients)and control group(20 patients) randomly .Twenty two pa-tients in the study group were gave antibiotics prophylaxis before the symptoms of the fungal infection appeared ,20 patients in the control group were only treated by antibiotics after the symptoms of fungal infection appeared .Charac-teristics of infection and the treatment effect in the two groups were compared .Results The incidence of pulmonary fungal infection in the study goup was 54 .5% ,which was significant lower than 95% of the control group (P<0 .01) .In 31 ICU patients ,Candida albicans was the highest proportion of pulmonary fungal infection ,with the rate as 83 .9% ,which was significant higher than that of Candida glabrata (9 .7% ) and Candida parapsilosis (6 .5% ) .Con-clusion Adopting antibiotics prophylaxis on the patients with pulmonary fungal infection could improve the effect , but should pay attention to rational drug using and disease characteristics .