CAJ | 학술논문

目的：探讨血清肿瘤标志物NSE和CA-125在非霍奇金淋巴瘤（ NHL）中的表达情况及临床意义。方法采用电化学发光免疫测定法测定56例NHL患者血清肿瘤标志物NSE和CA-125的表达水平，判定NSE和CA-125的表达与NHL患者临床特征及其预后的相关性。结果56例NHL患者化疗前血清NSE值（34 U．63±8．54）μg/L，CA-125（47．59±9．53）μg/L，均明显高于对照组，差异有统计学意义（ P ＜0．05）；且NSE、CA-125表达水平的高低与NHL患者B症状、临床分期、IPI预后指数及治疗效果等临床特征相关（ P ＜0．05）。结论血清肿瘤标志物NSE、CA-125联合定量检测可提高NHL诊断敏感性，同时对NHL临床分期、疗效判定及预后等方面具有一定临床意义。
목적：탐토혈청종류표지물NSE화CA-125재비곽기금림파류（ NHL）중적표체정황급림상의의。방법채용전화학발광면역측정법측정56례NHL환자혈청종류표지물NSE화CA-125적표체수평，판정NSE화CA-125적표체여NHL환자림상특정급기예후적상관성。결과56례NHL환자화료전혈청NSE치（34 U．63±8．54）μg/L，CA-125（47．59±9．53）μg/L，균명현고우대조조，차이유통계학의의（ P ＜0．05）；차NSE、CA-125표체수평적고저여NHL환자B증상、림상분기、IPI예후지수급치료효과등림상특정상관（ P ＜0．05）。결론혈청종류표지물NSE、CA-125연합정량검측가제고NHL진단민감성，동시대NHL림상분기、료효판정급예후등방면구유일정림상의의。
Objective To investigate the clinical significance of the two serum tumor markers-neuron specific enolase ( NSE) and carbohydrate antigen 125 ( CA-125 ) in the diagnosis and prognosis evaluation of non-Hodgkin ’ s lymphoma ( NHL) .Methods The serum levels of NSE and CA-125 in 56 patients with NHL were measured by electroche miluminescence immunoassay .The correlation between the expressions of NSE , CA125 and clinical characteristics as well as prognosis of patients with NHL were analyzed.Results Before chemotherapy the serum levels of NSE [( 34.63 ± 8.54)μg/L] and CA-125 [(47.59 ±9.53)μg/L] in 56 patients with NHL were significantly higher than those in control group ( P <0.05),furthermore,the expression levels of NSE and CA-125 were correlated with patient ’s symptoms,clinical stage,IPI prognosis index and therapeutic effect.Conclusion The quantitive detection of NSE combined with CA 125 plays an important role in diagnosis,clinical staging and prognosis assessment for patients with NHL ,which can increase diagnostic sensitivity.