药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
4期
218-219
,共2页
丙氨酰谷氨酰胺%尿素
丙氨酰穀氨酰胺%尿素
병안선곡안선알%뇨소
Alanyl glutamine%Urea
1例93岁女性患者因反复呕吐、进食困难入院,肾功能检查示血清肌酐90 μmol/L,尿素10 mmol/L.给予复方氨基酸注射液500 ml和丙氨酰谷氨酰胺注射液100 ml静脉滴注,1次/d.入院第5天患者血清肌酐122 μmol/L,尿素51 mmol/L,未予特殊处理.第12天血清肌酐120 μmol/L,尿素62 mmol/L,K+6.0 mmol/L,Na+ 157 mmol/L,Cl-134 mmol/L.患者出现神志模糊.停用复方氨基酸和丙氨酰谷氨酰胺注射液,同时控制钾、钠和补液量.4d后因患者病情再次给予肠外营养液,但仅静脉滴注复方氨基酸注射液500 ml/d,共1周.复查血清肌酐126 μmol/L,尿素29.7 mmol/L.此后患者尿素水平未再升高.
1例93歲女性患者因反複嘔吐、進食睏難入院,腎功能檢查示血清肌酐90 μmol/L,尿素10 mmol/L.給予複方氨基痠註射液500 ml和丙氨酰穀氨酰胺註射液100 ml靜脈滴註,1次/d.入院第5天患者血清肌酐122 μmol/L,尿素51 mmol/L,未予特殊處理.第12天血清肌酐120 μmol/L,尿素62 mmol/L,K+6.0 mmol/L,Na+ 157 mmol/L,Cl-134 mmol/L.患者齣現神誌模糊.停用複方氨基痠和丙氨酰穀氨酰胺註射液,同時控製鉀、鈉和補液量.4d後因患者病情再次給予腸外營養液,但僅靜脈滴註複方氨基痠註射液500 ml/d,共1週.複查血清肌酐126 μmol/L,尿素29.7 mmol/L.此後患者尿素水平未再升高.
1례93세녀성환자인반복구토、진식곤난입원,신공능검사시혈청기항90 μmol/L,뇨소10 mmol/L.급여복방안기산주사액500 ml화병안선곡안선알주사액100 ml정맥적주,1차/d.입원제5천환자혈청기항122 μmol/L,뇨소51 mmol/L,미여특수처리.제12천혈청기항120 μmol/L,뇨소62 mmol/L,K+6.0 mmol/L,Na+ 157 mmol/L,Cl-134 mmol/L.환자출현신지모호.정용복방안기산화병안선곡안선알주사액,동시공제갑、납화보액량.4d후인환자병정재차급여장외영양액,단부정맥적주복방안기산주사액500 ml/d,공1주.복사혈청기항126 μmol/L,뇨소29.7 mmol/L.차후환자뇨소수평미재승고.
A 93-year-old woman was hospitalized with repeated vomiting and difficulty in eating.Renal function test showed the following results:creatinine (Cr) 90μmol/L,blood urea nitrogen (BUN) 10mmol/L.An Ⅳ infusion of amino acid compound injection 500 ml and alanyl glutamine injection 100 ml were given once daily.On day 5 after administration,the renal function test showed the following results:Cr 122 μmol/L,BUN 51 mmol/L.No special treatment was given.On day 12 after administration,laboratory tests revealed the following levels:Cr 120 μmol/L,BUN 62 mmol/L,K + 6.0 mmol/L,Na + 157 mmol/L,C1-134 mmol/L.The patient developed mental confusion.Amino acid compound injection and alanyl glutamine injection were stopped.The supplement volume of potassium,sodium,and fluid were adjusted at the same time.Four days later,the patient received parenteral-nutrition solution again due to her condition.An Ⅳ infusion of only amino acid compound injection 500 ml once daily was given for one week.Laboratory review showed the following results:Cr 126 μmol/L,BUN 29.7 mmol/L.Henceforth,her BUN level did not increase again.
