CAJ | 학술논문

目的：观察冠心病患者血清亲环素 A（CyPA）水平变化，探讨其临床意义。方法64例确诊冠心病的患者（冠心病组），依临床类型分为稳定型心绞痛组（SAP组）、不稳定型心绞痛组（UAP组）、急性心肌梗死组（AMI组）；依冠状动脉病变范围分为单支组、双支组、多支组；26例检查正常者为对照组。采用 ELISA法测CyPA和基质金属蛋白酶9（MMP-9）水平，免疫散射比浊法测C-反应蛋白（CRP）水平。结果冠心病组 CyPA、MMP-9、CRP 明显高于对照组（P＜0．01）；AMI组、UAP 组 CyPA、MMP-9、CRP明显高于对照组和 SAP组（P＜0．05），SAP 组 CyPA、CRP 与对照组差异无统计学意义（P＞0．05）；单支组、双支组、多支组CyPA、MMP-9、CRP显著高于对照组（P＜0．05），CyPA、MMP-9、CRP随冠脉病变支数增多而升高（P＜0．05）。冠心病组CyPA与 MMP-9、CRP呈明显正相关（r＝0．772、0．749，P＜0．01）。结论冠心病患者 CyPA明显升高，CyPA可能与冠心病及斑块稳定性有一定关系。
목적：관찰관심병환자혈청친배소 A（CyPA）수평변화，탐토기림상의의。방법64례학진관심병적환자（관심병조），의림상류형분위은정형심교통조（SAP조）、불은정형심교통조（UAP조）、급성심기경사조（AMI조）；의관상동맥병변범위분위단지조、쌍지조、다지조；26례검사정상자위대조조。채용 ELISA법측CyPA화기질금속단백매9（MMP-9）수평，면역산사비탁법측C-반응단백（CRP）수평。결과관심병조 CyPA、MMP-9、CRP 명현고우대조조（P＜0．01）；AMI조、UAP 조 CyPA、MMP-9、CRP명현고우대조조화 SAP조（P＜0．05），SAP 조 CyPA、CRP 여대조조차이무통계학의의（P＞0．05）；단지조、쌍지조、다지조CyPA、MMP-9、CRP현저고우대조조（P＜0．05），CyPA、MMP-9、CRP수관맥병변지수증다이승고（P＜0．05）。관심병조CyPA여 MMP-9、CRP정명현정상관（r＝0．772、0．749，P＜0．01）。결론관심병환자 CyPA명현승고，CyPA가능여관심병급반괴은정성유일정관계。
Objective To observe the serum cyclophilin A(CyPA)level change in the patients with coronary heart disease (CHD)and to investigate its clinical significance.Methods 64 patients with CHD(CHD group)were divided into three groups ac-cording to the clinical types:stable angina pectoris(SAP)group,unstable angina pectoris(UAP)group and acute myocardial infarc-tion(AMI)group;which were divided into three groups according to the coronary artery lesion range:single vessel lesion group, double vessels lesions group and multi vessels lesions group;while 26 controls with normal coronary arteries were select as the con-trol group.Serum levels of CyPA and matrix metalloproteinase-9 (MMP-9 )were detected by ELISA,and C-reactive protein(CRP) concentration was detected by the immune scattering turbidimetry test.Results The CyPA,MMP-9 and CRP levels in the CHD group were significantly higher than those in the control group(P<0.01);the CyPA and CRP levels in the AMI group and the UAP group were significantly higher than those in the control group and the SAP group(P<0.05),the CyPA and CRP levels had no statistically significant difference between the SAP group and the control group(P>0.05);serum CyPA,MMP-9 and CRP levels in the single vessel lesion group,the double vessels lesion group,multi vessels lesion group were significantly higher than those in the control group(P<0.05),serum CyPA,MMP-9 and CRP levels were elevated with the increase of coronary artery lesion vessels (P<0.05).In the CHD group,serum CyPA with MMP-9 and CRP showed the significantly positive correlation(r=0.772,0.749, P<0.01).Conclusion Serum CyPA level is significantly increased in the patients with CHD,CyPA may have some relationship to CHD and the plaque stability.