CAJ | 학술논문

目的：研究探讨益赛普用于治疗多关节型幼年特发性关节炎的临床疗效和安全性。方法随机选出江西省儿童医院多关节型幼年特发性关节炎患儿40例，分为常规治疗组和益赛普组（n=20），常规治疗组使用常规抗风湿药物治疗，益赛普组在常规抗风湿药物的基础上，加用益赛普0.5 mg/kg皮下注射治疗，每周2次，连续治疗3个月。比较2组治疗2、4、8和12周时的有效率，红细胞沉降率，C反应蛋白水平和不良反应发生率的差异。结果益赛普组治疗2、4、8和12周时的有效率均高于常规治疗组，红细胞沉降率，C反应蛋白水平和不良反应发生率均明显低于常规治疗组，2组比较差异有统计学意义（P<0.05）。结论益赛普对于多关节型幼年特发性关节炎患者效果显著，安全性高，值得临床广泛推广使用。
목적：연구탐토익새보용우치료다관절형유년특발성관절염적림상료효화안전성。방법수궤선출강서성인동의원다관절형유년특발성관절염환인40례，분위상규치료조화익새보조（n=20），상규치료조사용상규항풍습약물치료，익새보조재상규항풍습약물적기출상，가용익새보0.5 mg/kg피하주사치료，매주2차，련속치료3개월。비교2조치료2、4、8화12주시적유효솔，홍세포침강솔，C반응단백수평화불량반응발생솔적차이。결과익새보조치료2、4、8화12주시적유효솔균고우상규치료조，홍세포침강솔，C반응단백수평화불량반응발생솔균명현저우상규치료조，2조비교차이유통계학의의（P<0.05）。결론익새보대우다관절형유년특발성관절염환자효과현저，안전성고，치득림상엄범추엄사용。
Objective To study the clinical efficacy and safety of etanercept for the treatment of juvenile idiopathic arthritis.Methods20 patients in conventional group treated by conventional anti-rheumatic drug for 3 months. 20 patients in etanercept group treated by etanercept twice a week for 3 months, and etantercept group treated by both conventional anti-rheumatic drug.The efficiency,erythrocyte sedimentation rate,C-reactive protein levels and incidence of adverse reactions of 2、4、8and12weeks were compared.Results The effective of 2、4、8and12weeks of experimental group higher,erythrocyte sedimentation rate,C-reactive protein level and incidence of adverse reactions were all signiifcantly lower in the etanercept group than those in the conventionl group.The difference was statistically signiifcance(P<0.05).ConclusionThe efifcency of etanercept for treating much better and safer than conventionl treatment.Etanercept is worthy of clinical usage for JIA patients.