CAJ | 학술논문

目的：了解当地艾滋病（AIDS）患者高效抗逆转录病毒治疗（HAART）效果，分析影响治疗效果的因素，提高抗病毒治疗质量。方法定期随访监测 HAART患者CD4 T淋巴细胞，观察抗病毒治疗效果。结果在24个月随访监测期中，102例抗病毒治疗患者CD4 T淋巴细胞计数逐步增加，前3个月增加较明显（P＜0．01），吸毒患者和性传患者 CD4 T淋巴细胞计数组内比较差异无统计学意义（P＞0．05），11例病死患者CD4 T淋巴细胞基线均数小于200个/μL，治疗3个月后CD4 T淋巴细胞计数较基线差异无统计学意义（P＞0．05）。结论该群 AIDS患者 HAART的免疫学疗效不理想。
목적：료해당지애자병（AIDS）환자고효항역전록병독치료（HAART）효과，분석영향치료효과적인소，제고항병독치료질량。방법정기수방감측 HAART환자CD4 T림파세포，관찰항병독치료효과。결과재24개월수방감측기중，102례항병독치료환자CD4 T림파세포계수축보증가，전3개월증가교명현（P＜0．01），흡독환자화성전환자 CD4 T림파세포계수조내비교차이무통계학의의（P＞0．05），11례병사환자CD4 T림파세포기선균수소우200개/μL，치료3개월후CD4 T림파세포계수교기선차이무통계학의의（P＞0．05）。결론해군 AIDS환자 HAART적면역학료효불이상。
Objective To understand the effect of the highly active antiretroviral therapy(HAART)in the local AIDS patients and to analyzes the factors affecting the treatment effect for improving the quality of antiviral therapy.Methods The CD4 T lym-phocyte count in the patients with HAART was regularly followed-up and monitored,and the antiviral treatment effect was ob-served.Results During 24-month follow-up monitoring period,the CD4 T lymphocyte count in 102 cases of HAART was gradually increased,the increase during the first 3 months was more obvious(P<0.01),the intra-group comparison showed that CD4 T lym-phocyte count in the drug-taking patients and the sexually transmitted patients had no statistical difference(P>0.05),the baseline mean of CD4 T lymphocyte count from 11 dead patients was less than 200/μL,but the CD4 T lymphocyte count after 3-month treatment had no statistical difference compared with the baseline mean(P>0.05).Conclusion The immunological effect of HAAR in the group AIDS patients is poor.