CAJ | 학술논문

目的：观察尿毒清颗粒联合血管紧张素转换酶抑制剂（ACEI）或血管紧张素受体拮抗剂（ARB）类药物对糖尿病肾病不同分期的疗效。方法将46例糖尿病肾病患者分为对照组和治疗组，每组各23例。两组患者均常规降糖治疗，对照组给予ACEI或ARB类药物；治疗组在对照组治疗的基础上联用尿毒清颗粒每日4次，每次5 g ，连续服药4周，观察治疗前后24 h尿微量蛋白、24 h尿蛋白定量、血肌酐、尿素氮、胱抑素的变化。结果两组治疗后24 h尿微量蛋白、24 h蛋白定量均较治疗前减少（P＜0．01）。对于糖尿病肾病Ⅲ期患者，治疗组和对照组在减少尿蛋白的治疗上差异无统计学意义（P＞0．05），对于糖尿病肾病Ⅳ期患者，治疗组较对照组尿蛋白明显减少（P＜0．05）。结论 ACEI或ARB类药物联合尿毒清颗粒治疗糖尿病肾病大量蛋白尿患者疗效确切。
목적：관찰뇨독청과립연합혈관긴장소전환매억제제（ACEI）혹혈관긴장소수체길항제（ARB）류약물대당뇨병신병불동분기적료효。방법장46례당뇨병신병환자분위대조조화치료조，매조각23례。량조환자균상규강당치료，대조조급여ACEI혹ARB류약물；치료조재대조조치료적기출상련용뇨독청과립매일4차，매차5 g ，련속복약4주，관찰치료전후24 h뇨미량단백、24 h뇨단백정량、혈기항、뇨소담、광억소적변화。결과량조치료후24 h뇨미량단백、24 h단백정량균교치료전감소（P＜0．01）。대우당뇨병신병Ⅲ기환자，치료조화대조조재감소뇨단백적치료상차이무통계학의의（P＞0．05），대우당뇨병신병Ⅳ기환자，치료조교대조조뇨단백명현감소（P＜0．05）。결론 ACEI혹ARB류약물연합뇨독청과립치료당뇨병신병대량단백뇨환자료효학절。
Objective To observe the effects of Uremic Clearance Granule combined with angiotensin receptor blockers (ARB) or angiotensin converting enzyme inhibitors (ACEI) in treating different period of diabetic nephropathy (DN ) .Methods 46 patients with DN were divided into the control group and the treatment group ,23 cases in each group .The two groups were given the rou-tine hypoglycemic therapy .The control group was treated with ACEI or ARB ,while the treatment group was given Uremic Clear-ance Granule 5 g each time ,four times daily for successive 4 weeks .Then the indexes of serum creatinine ,blood urea nitrogen ,cysta-tin-C ,microalbumin and 24 h urine total protein at 24 h before and after treatment were observed .Results The microalbumin and 24 h urine total protein after treatment in the two groups were reduced compared with before treatment (P<0 .01) .In the patients with the stage Ⅲ of DN ,the urine protein decrease after treatment had no statistical difference between the two groups (P>0 .05) . In the patients with the stage Ⅳ of DN ,on the basis of ACEI or ARB adding Uremic Clearance Granule could significantly decrease the urine protein(P<0 .05) .Conclusion ACEI or ARB combined with Uremic Clearance Granule has definite effect for treating massive proteinuria of DN .