CAJ | 학술논문

目的：研究肿瘤转移相关基因1（MTA1）蛋白在喉癌组织中的表达特点，并分析其与基质金属蛋白酶9（MMP-9）、血管内皮生长因子C（VEGF-C）蛋白的相关性。方法采用Western blot法检测40例喉癌患者的正常喉黏膜组织、癌周围组织及肿瘤组织样本中MTA1、MMP-9、VEGF-C蛋白表达，并统计分析其临床病理特性。结果与喉癌无颈淋巴结转移组、癌周围及正常组织相比，喉癌颈淋巴结转移组中MTA1蛋白的表达水平明显升高（P＜0．05）。MTA1蛋白在喉癌组织中的表达与淋巴结转移、肿瘤分期及肿瘤分化程度呈正相关（P＜0．05），并与VEGF-C、MMP-9表达正相关（P＜0．05）。结论 MTA1可能参与喉癌的发生、发展和转移，且可能与MMP-9、VEGF-C蛋白之间存在调控作用。
목적：연구종류전이상관기인1（MTA1）단백재후암조직중적표체특점，병분석기여기질금속단백매9（MMP-9）、혈관내피생장인자C（VEGF-C）단백적상관성。방법채용Western blot법검측40례후암환자적정상후점막조직、암주위조직급종류조직양본중MTA1、MMP-9、VEGF-C단백표체，병통계분석기림상병리특성。결과여후암무경림파결전이조、암주위급정상조직상비，후암경림파결전이조중MTA1단백적표체수평명현승고（P＜0．05）。MTA1단백재후암조직중적표체여림파결전이、종류분기급종류분화정도정정상관（P＜0．05），병여VEGF-C、MMP-9표체정상관（P＜0．05）。결론 MTA1가능삼여후암적발생、발전화전이，차가능여MMP-9、VEGF-C단백지간존재조공작용。
Objective To investigate the expression characteristic of metastasis associated 1(MTA1) protein in laryngocarcino-ma tissue and to analyze its relationship with matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor C(VEGF-C) proteinin .Methods The Western blot method was adopt to detect the expression levels of MTA1 ,MMP-9 and VEGF-C protein in the specimens of normal laryngeal mucosal tissue ,paracarcinoma tissue and tumor tissue from 40 cases of laryngocarcinoma .Re-sults Compared with the groups of laryngocarcinoma without lymph node metastasis ,paracarcinoma and normal tissue ,the expres-sion level of MTA1 protein in the laryngocarcinoma with lymph node metastasis group was significantly increased (P<0 .05) .The expression of MTA1 protein in the laryngocarcinoma tissue was significantly correlated with the lymph nodes metastasis ,tumor staging and differentiation degree of laryngocarcinoma (P<0 .05) and was positively correlated with the expression of VEGF-C and MMP-9 (P<0 .05) .Conclusion MTA1 may participate in the development ,progress and metastasis of laryngocarcinoma .Moreo-ver the regulating effect may exist among MTA1 ,MMP-9 and VEGF-C .