CAJ | 학술논문

目的：观察止痛四物汤对肾虚血瘀型膝骨性关节炎患者关节液中MMP-3、N0、IL-1的影响。方法：将60例符合标准的膝骨关节炎患者按随机数字表法分为两组，每组30例。Ⅰ组患者口服美洛昔康分散片；Ⅱ组患者口服中药止痛四物汤。分别于治疗前、治疗后3周及6周抽取膝关节液检测MMP-3、NO、IL-1的含量。结果：治疗前和治疗3周后两组间的MMP-3、NO、IL-1含量比较差异均无统计学意义（P>0.05）；治疗6周后Ⅱ组的MMP-3、NO、IL-1含量均较Ⅰ组下降明显，差异均有统计学意义（P<0.05）。结论：止痛四物汤能降低肾虚血瘀型膝骨性关节炎患者关节液中MMP-3、NO、IL-1的含量，抑制炎性反应，值得临床推广。
목적：관찰지통사물탕대신허혈어형슬골성관절염환자관절액중MMP-3、N0、IL-1적영향。방법：장60례부합표준적슬골관절염환자안수궤수자표법분위량조，매조30례。Ⅰ조환자구복미락석강분산편；Ⅱ조환자구복중약지통사물탕。분별우치료전、치료후3주급6주추취슬관절액검측MMP-3、NO、IL-1적함량。결과：치료전화치료3주후량조간적MMP-3、NO、IL-1함량비교차이균무통계학의의（P>0.05）；치료6주후Ⅱ조적MMP-3、NO、IL-1함량균교Ⅰ조하강명현，차이균유통계학의의（P<0.05）。결론：지통사물탕능강저신허혈어형슬골성관절염환자관절액중MMP-3、NO、IL-1적함량，억제염성반응，치득림상추엄。
Objective:To observe the impact of the Zhitong Siwu decoction on the levels of MMP-3,NO,IL-1 in synovial fluid in patients with knee osteoarthritis(KOA)of renal deficiency and blood stasis.Method:60 KOA patients who met criteria were randomly divided into two groups,30 cases in each group. The group I orally took Meloxicam Dispersible Tablets,while the group II orally took traditional Chinese medicine(TCM)Zhitong Siwu decoction. Levels of MMP-3,NO,IL-1 in synovial fluid of the two groups were tested before treatment,3 weeks and 6 weeks after treatment respectively.Result:Before treatment and 3 weeks after treatment,the levels of MMP-3,NO,IL-1 in the two groups were compared,and there were no statistical differences(P>0.05). 6 weeks after treatment,levels of MMP-3,NO,IL-1 of the group II were all noticeably lower than those of the group I,there were statistical differences(P<0.05).Conclusion:Zhitong Siwu decoction can reduce levels of MMP-3,NO,IL-1 in synovial fluid in patients with knee osteoarthritis of renal deficiency and blood stasis,contain inflammatory response and thus deserve clinical promotion.