中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
27期
57-60
,共4页
乌司他丁%新生儿脓毒血症%疗效
烏司他丁%新生兒膿毒血癥%療效
오사타정%신생인농독혈증%료효
Ulinastatin%Neonatal sepsis%Clinical effect
目的:观察乌司他丁治疗新生儿脓毒症的临床效果。方法:将48例新生儿脓毒症患儿按随机数字表法分为治疗组(n=25)和对照组(n=23)。对照组给予常规治疗,治疗组在常规治疗的基础上加用乌司他丁,比较两组治疗前后的体温(T)、呼吸(RR)、心率(HR)、白细胞计数(WBC)、肝肾功能等指标的变化,同时比较两组治疗有效率及病死率的变化。结果:两组治疗后T、R、HR、WBC均较治疗前明显改善(P<0.05);两组的血浆CRP、PCT、ALT、TBIL、DBIL、Cr、BUN、LDH、CK-MB、PT、APTT、D-D、IL-6、TNF-α、NSE较前均明显下降(P<0.05),FIB、IL-10较前明显升高(P<0.05),且乌司他丁组除Cr、BUN外,上述其余指标较对照组改变更明显(P<0.05)。两组的有效率比较差异有统计学意义(P<0.05);两组的病死率比较差异无统计学意义(P>0.05)。结论:乌司他丁治疗新生儿脓毒症具有良好的临床疗效,值得临床推广应用。
目的:觀察烏司他丁治療新生兒膿毒癥的臨床效果。方法:將48例新生兒膿毒癥患兒按隨機數字錶法分為治療組(n=25)和對照組(n=23)。對照組給予常規治療,治療組在常規治療的基礎上加用烏司他丁,比較兩組治療前後的體溫(T)、呼吸(RR)、心率(HR)、白細胞計數(WBC)、肝腎功能等指標的變化,同時比較兩組治療有效率及病死率的變化。結果:兩組治療後T、R、HR、WBC均較治療前明顯改善(P<0.05);兩組的血漿CRP、PCT、ALT、TBIL、DBIL、Cr、BUN、LDH、CK-MB、PT、APTT、D-D、IL-6、TNF-α、NSE較前均明顯下降(P<0.05),FIB、IL-10較前明顯升高(P<0.05),且烏司他丁組除Cr、BUN外,上述其餘指標較對照組改變更明顯(P<0.05)。兩組的有效率比較差異有統計學意義(P<0.05);兩組的病死率比較差異無統計學意義(P>0.05)。結論:烏司他丁治療新生兒膿毒癥具有良好的臨床療效,值得臨床推廣應用。
목적:관찰오사타정치료신생인농독증적림상효과。방법:장48례신생인농독증환인안수궤수자표법분위치료조(n=25)화대조조(n=23)。대조조급여상규치료,치료조재상규치료적기출상가용오사타정,비교량조치료전후적체온(T)、호흡(RR)、심솔(HR)、백세포계수(WBC)、간신공능등지표적변화,동시비교량조치료유효솔급병사솔적변화。결과:량조치료후T、R、HR、WBC균교치료전명현개선(P<0.05);량조적혈장CRP、PCT、ALT、TBIL、DBIL、Cr、BUN、LDH、CK-MB、PT、APTT、D-D、IL-6、TNF-α、NSE교전균명현하강(P<0.05),FIB、IL-10교전명현승고(P<0.05),차오사타정조제Cr、BUN외,상술기여지표교대조조개변경명현(P<0.05)。량조적유효솔비교차이유통계학의의(P<0.05);량조적병사솔비교차이무통계학의의(P>0.05)。결론:오사타정치료신생인농독증구유량호적림상료효,치득림상추엄응용。
Objective:To observe the clinical effect of ulinastatin in treating neonatal sepsis.Method:48 cases of neonatal sepsis were randomly divided into the treatment group(n=25)and the control group(n=23). The control group just received conventional therapy,while the treatment group added ulinastatin. The indexs of temperature(T),respiration rate(RR),heart rate(HR),white blood cell count(WBC),liver and kidney function,and so on of the two groups were compared,and treatment efficiency and case-fatality rate between pre-treatment and post-treatment were compared too. Result:The two groups obtained improvement in T,R,HR,WBC than pre-treatment(P<0.05);and the CRP,PCT, ALT,TBIL,DBIL,Cr,BUN,LDH,CK-MB,PT,APTT,D-D,IL-6,TNF-α,NSE levels decreased significantly in plasma in both groups after treatment(P<0.05);and the FIB,IL-10 levels increased significantly in both groups (P<0.05). The above indicators except Cr,BUN in the treatment group changed more significantly than the control group (P<0.05). The difference of efficient between the two groups was statistically significant(P<0.05);the case fatality rate of the two groups had no statistical significance(P>0.05).Conclusion:Ulinastatin is effective in treating of neonatal sepsis patients and it deserve to be applied universally.