CAJ | 학술논문

目的早孕期超声全面观察胎儿发育情况,探讨11 ～ 13+6周胎儿系统超声检查早期诊断胎儿畸形的临床价值.方法本研究在2328例孕11 ～ 13+6周孕妇开展了胎儿系统超声检查,全面筛查胎儿大脑、骨骼、心血管系统、神经系统及泌尿系统等各系统畸形,追踪胎儿引产后情况、中晚孕超声情况及新生儿情况,综合分析早孕期超声检查的临床意义.结果胎儿畸形总例数为105例,发生率为4.51％,早孕期超声检出例数50例,检出率为47.61％.除了消化系统、呼吸系统、泌尿系统畸形没有检出外,其他胎儿畸形在早孕期超声检查中均有发现.心血管异常、神经系统异常、骨骼四肢异常、颜面部畸形、前腹壁畸形、颈部NT增厚及颈部水囊瘤和多胎特有畸形(无心序列)早孕期检出率分别为8.00％、72.70％、73.33％、33.33％、75.00％、100.00％和100.00％.早孕期超声检查胎儿畸形的特异性达到100.00％.结论 11～ 13+6周胎儿系统超声检查有助于胎儿严重畸形的早期发现,建立早孕期胎儿系统超声检查技术标准,开展规范化培训将对优生优育具有重要意义.
목적 조잉기초성전면관찰태인발육정황,탐토11 ～ 13+6주태인계통초성검사조기진단태인기형적림상개치.방법 본연구재2328례잉11 ～ 13+6주잉부개전료태인계통초성검사,전면사사태인대뇌、골격、심혈관계통、신경계통급비뇨계통등각계통기형,추종태인인산후정황、중만잉초성정황급신생인정황,종합분석조잉기초성검사적림상의의.결과 태인기형총례수위105례,발생솔위4.51％,조잉기초성검출례수50례,검출솔위47.61％.제료소화계통、호흡계통、비뇨계통기형몰유검출외,기타태인기형재조잉기초성검사중균유발현.심혈관이상、신경계통이상、골격사지이상、안면부기형、전복벽기형、경부NT증후급경부수낭류화다태특유기형(무심서렬)조잉기검출솔분별위8.00％、72.70％、73.33％、33.33％、75.00％、100.00％화100.00％.조잉기초성검사태인기형적특이성체도100.00％.결론 11～ 13+6주태인계통초성검사유조우태인엄중기형적조기발현,건립조잉기태인계통초성검사기술표준,개전규범화배훈장대우생우육구유중요의의.
Objective To evaluate the clinical implication of fetal ultrasonic examination during 11-13+6 gestational weeks in early diagnosis of fetal malformation.Methods Ultrasonic examinations were carried out in 2328 pregnant women who were on the 11-13+6 gestational weeks pregnant period to investigate the fetal malformation of brain,bone,cardiovascular system,nervous system,urinary system and so on.We also tracked the fetus situation after induced labor,situation of middle-late pregnancy ultrasound and newborn babies.After all,the clinical significance of ultrasonic examination was evaluated.Results The total cases number of fetal malformation was 105,the incidence rate was 4.51％.50 cases were detected by the present ultrasound examination during 11-13+6 gestational weeks,the sensitivity rate of the present study was 47.61％.Except for the abnormality of digestive system,respiratory system and urinary system,other fetal malformations were found in the present ultrasound examination.The detection rates of cardiovascular abnormalities,nervous system abnormalities,skeletal limb abnormalities,facial deformity,anterior abdominal wall defects,carotid NT thickening and cystic hygroma and multiple malformations (a unique sequence) were 8％,72.70％,73.33％,33.33％,75％,100％ and 100％ respectively.The specificity of early pregnancy ultrasound examination for fetal malformation reached 100％.Conclusion 11-13+6 gestational weeks fetal ultrasound examination is helpful to the early diagnosis of fetal malformation.Building pregnancy ultrasound technological standard,carrying out standardized training will be of great significance in eugenics.