中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
34期
34-36
,共3页
于学勇%姚树娈%刘慧红%林祥晓%丁宇
于學勇%姚樹孌%劉慧紅%林祥曉%丁宇
우학용%요수련%류혜홍%림상효%정우
肺栓塞%D-二聚体%乳酸脱氢酶%组织型纤溶酶原激活物
肺栓塞%D-二聚體%乳痠脫氫酶%組織型纖溶酶原激活物
폐전새%D-이취체%유산탈경매%조직형섬용매원격활물
Pulmonary embolism%D-dimer%Lactate dehydrogenases%Tissue plasminogen activator
目的 探讨血浆D-二聚体(DD)、乳酸脱氢酶同工酶3(LDH3)、组织型纤溶酶原激活物(t-PA)在早期急性肺栓塞患者中的变化及其临床意义.方法 选取46例早期急性肺栓塞患者(肺栓塞组)及同期门诊正常体检无异常者50例(对照组),急性肺栓塞患者按照病情分为低危18例,中危15例,高危13例,对其进行DD、LDH3及t-PA检测.结果 肺栓塞组DD、LDH3及t-PA分别为(2.95±0.73) mg/L、(421.42±63.29) U/L、(0.85±0.02) U/L,对照组分别为(0.03±0.01) mg/L、(198.17±23.37) U/L、(0.59±0.02) U/L,肺栓塞组DD、LDH3及t-PA明显高于对照组(P＜0.05).低危患者DD、LDH3、t-PA分别为(1.49±0.04) mg/L、(315.47±38.24) U/L、(0.63±0.01) U/L,中危患者分别为(2.22±0.27) mg/L、(382.41±54.36) U/L、(0.79±0.02) U/L,高危患者分别为(3.38±0.98)mg/L、(583.93±117.21) U/L、(0.92±0.03) U/L,中、高危患者与低危患者比较差异有统计学意义(P＜0.05)；高危患者LDH3、t-PA与中危患者比较差异有统计学意义(P＜0.05).肺栓塞组治疗后DD、LDH3、t-PA分别为(1.03±0.11) mg/L、(223.24±25.04) U/L、(0.62±0.02) U/L,较治疗前明显下降(P＜0.05).结论 在早期急性肺栓塞患者中DD、LDH3及t-PA均明显升高,随着病情缓解会逐渐下降,联合检测有助于急性肺栓塞的早期诊断.
目的 探討血漿D-二聚體(DD)、乳痠脫氫酶同工酶3(LDH3)、組織型纖溶酶原激活物(t-PA)在早期急性肺栓塞患者中的變化及其臨床意義.方法 選取46例早期急性肺栓塞患者(肺栓塞組)及同期門診正常體檢無異常者50例(對照組),急性肺栓塞患者按照病情分為低危18例,中危15例,高危13例,對其進行DD、LDH3及t-PA檢測.結果 肺栓塞組DD、LDH3及t-PA分彆為(2.95±0.73) mg/L、(421.42±63.29) U/L、(0.85±0.02) U/L,對照組分彆為(0.03±0.01) mg/L、(198.17±23.37) U/L、(0.59±0.02) U/L,肺栓塞組DD、LDH3及t-PA明顯高于對照組(P＜0.05).低危患者DD、LDH3、t-PA分彆為(1.49±0.04) mg/L、(315.47±38.24) U/L、(0.63±0.01) U/L,中危患者分彆為(2.22±0.27) mg/L、(382.41±54.36) U/L、(0.79±0.02) U/L,高危患者分彆為(3.38±0.98)mg/L、(583.93±117.21) U/L、(0.92±0.03) U/L,中、高危患者與低危患者比較差異有統計學意義(P＜0.05)；高危患者LDH3、t-PA與中危患者比較差異有統計學意義(P＜0.05).肺栓塞組治療後DD、LDH3、t-PA分彆為(1.03±0.11) mg/L、(223.24±25.04) U/L、(0.62±0.02) U/L,較治療前明顯下降(P＜0.05).結論 在早期急性肺栓塞患者中DD、LDH3及t-PA均明顯升高,隨著病情緩解會逐漸下降,聯閤檢測有助于急性肺栓塞的早期診斷.
목적 탐토혈장D-이취체(DD)、유산탈경매동공매3(LDH3)、조직형섬용매원격활물(t-PA)재조기급성폐전새환자중적변화급기림상의의.방법 선취46례조기급성폐전새환자(폐전새조)급동기문진정상체검무이상자50례(대조조),급성폐전새환자안조병정분위저위18례,중위15례,고위13례,대기진행DD、LDH3급t-PA검측.결과 폐전새조DD、LDH3급t-PA분별위(2.95±0.73) mg/L、(421.42±63.29) U/L、(0.85±0.02) U/L,대조조분별위(0.03±0.01) mg/L、(198.17±23.37) U/L、(0.59±0.02) U/L,폐전새조DD、LDH3급t-PA명현고우대조조(P＜0.05).저위환자DD、LDH3、t-PA분별위(1.49±0.04) mg/L、(315.47±38.24) U/L、(0.63±0.01) U/L,중위환자분별위(2.22±0.27) mg/L、(382.41±54.36) U/L、(0.79±0.02) U/L,고위환자분별위(3.38±0.98)mg/L、(583.93±117.21) U/L、(0.92±0.03) U/L,중、고위환자여저위환자비교차이유통계학의의(P＜0.05)；고위환자LDH3、t-PA여중위환자비교차이유통계학의의(P＜0.05).폐전새조치료후DD、LDH3、t-PA분별위(1.03±0.11) mg/L、(223.24±25.04) U/L、(0.62±0.02) U/L,교치료전명현하강(P＜0.05).결론 재조기급성폐전새환자중DD、LDH3급t-PA균명현승고,수착병정완해회축점하강,연합검측유조우급성폐전새적조기진단.
Objective To explore the change of plasma D-dimer (DD),lactate dehydrogenase isoenzyme 3 (LDH3),tissue plasminogen activator (t-PA) in the early stage of acute pulmonary embolism and their clinical significance.Methods Forty-six patients with acute pulmonary embolism of early stage (pulmonary embolism group) and 50 cases of normal person (control group) were enrolled in this study.The patients in pulmonary embolism group were divided into low-risk(18 patients),middle-risk(15 patients) and higher-risk (13 patients).The levels of DD,LDH3 and t-PA were detected and compared.Results The levels of DD,LDH3 and t-PA in pulmonary embolism group were (2.95 ± 0.73) mg/L,(421.42 ± 63.29)U/L and (0.85 ±0.02) U/L,and significantly higher than those in control group [(0.03 ±0.01) mg/L,(198.17 ± 23.37) U/L and (0.59 ± 0.02) U/L] (P ＜ 0.05).The levels of DD,LDH3 and t-PA in low-risk patients [(1.49 ± 0.04) mg/L,(315.47 ± 38.24) U/L and (0.63 ± 0.01) U/L] were significantly lower than those in middle-risk patients [(2.22 ±0.27) mg/L,(382.41 ±54.36) U/L and (0.79 ±0.02) U/L] and higher-risk patients [(3.38 ± 0.98) mg/L,(583.93 ± 117.21) U/L and (0.92 ± 0.03) U/L] (P ＜ 0.05).The levels of LDH3 and t-PA in middle-risk patients were significantly lower than those in higher-risk patients (P ＜ 0.05).After treatment,the levels of DD,LDH3 and t-PA were significantly decreased [(2.95 ± 0.73)mg/L vs.(1.03 ±0.11) mg/L,(421.42 ±63.29) U/L vs.(223.24 ±25.04) U/L,(0.85 ±0.02) U/L vs.(0.62 ± 0.02) U/L] (P ＜ 0.05).Conclusions The levels of DD,LDH3 and t-PA in the early stage of acute pulmonary embolism are increased significantly,and with the remission of the patient's condition,the levels of DD,LDH3 and t-PA are decreased.United detection conduces to the diagnosis of acute pulmonary embolism.
