CAJ | 학술논문

目的：探讨血液灌流（HP）联合血液透析（HD）治疗急性重度有机磷农药中毒的疗效。方法回顾分析我院2009年1月至2012年9月收治的急性重度有机磷农药中毒70例患者，根据家庭经济情况及家属意愿分为治疗组和对照组，治疗组在阿托品、胆碱酯酶（CHE）复能剂及对症支持治疗的基础上同时应用 HP联合HD治疗，对照组单纯使用阿托品、胆碱酯酶（CHE）复能剂及对症支持治疗，观察两组胆碱酯酶（CHE）活力恢复时间、昏迷病人清醒时间，判断HP联合HD治疗疗效。结果急性重度有机磷农药中毒患者，在阿托品、胆碱酯酶（CHE）复能剂及对症支持治疗的同时应用HP联合HD治疗，患者胆碱酯酶活性恢复时间、昏迷时间、住院时间等均显著短于对照组。结论 HP联合HD治疗治疗急性重度有机磷农药中毒是有效的，值得临床推广应用。
목적：탐토혈액관류（HP）연합혈액투석（HD）치료급성중도유궤린농약중독적료효。방법회고분석아원2009년1월지2012년9월수치적급성중도유궤린농약중독70례환자，근거가정경제정황급가속의원분위치료조화대조조，치료조재아탁품、담감지매（CHE）복능제급대증지지치료적기출상동시응용 HP연합HD치료，대조조단순사용아탁품、담감지매（CHE）복능제급대증지지치료，관찰량조담감지매（CHE）활력회복시간、혼미병인청성시간，판단HP연합HD치료료효。결과급성중도유궤린농약중독환자，재아탁품、담감지매（CHE）복능제급대증지지치료적동시응용HP연합HD치료，환자담감지매활성회복시간、혼미시간、주원시간등균현저단우대조조。결론 HP연합HD치료치료급성중도유궤린농약중독시유효적，치득림상추엄응용。
Objective To summarize the curative effect of hemoperfusion (HP) combine hemodialysis(HD) in treatment for severe acute or-ganophosphorus pesticides poisoning(SAOPP) .Methods 70 cases with SAOPP in our hospital from 01/2009 to 09/2012 were randomly divided in-to treatment group and control group .Both of them were given atropine ,cholinesterase(CHE) reactivator ,respiratory support and so on .Besides that ,HP combine HD were given to the treatment group .For both of two groups ,the time of CHE reactivate and the time of consciousness were observed to evaluate the curative effect of HP combine HD .The treatment group ,detection for serum CHE activity been used before and after treatment .Results HP combine HD were given to the treatment group beside given atropine ,cholinesterase(CHE) reactivator ,respiratory sup-port .The time of CHE reactivate and the time of consciousness were observed to evaluate the curative effect of HP combine HD .Conclusion The rate of CHE activity increased significantly after the treatment with HP combine HD .