CAJ | 학술논문

目的：探讨卡介苗在调节Th细胞的免疫失衡、改善哮喘发作时气道炎症反应的可能机制。方法随机将208名PPD试验阴性的哮喘患者分为干预组和常规治疗组，观察6个月，于治疗前后评估两组肺功能及血清IL-4、IFN-γ、IL-12水平的变化。结果两组治疗后肺功能均较治疗前有改善（P＜0．05），治疗后干预组较常规治疗组肺功能改善明显，差异有显著性（P＜0．05）；治疗后干预组较常规治疗组 IFN-γ、IL-12升高明显，IL-4下降更明显，差异有统计学意义（P＜0．05）。结论卡介苗通过调节哮喘患者Thl/Th2比例失衡改善肺功能。
목적：탐토잡개묘재조절Th세포적면역실형、개선효천발작시기도염증반응적가능궤제。방법수궤장208명PPD시험음성적효천환자분위간예조화상규치료조，관찰6개월，우치료전후평고량조폐공능급혈청IL-4、IFN-γ、IL-12수평적변화。결과량조치료후폐공능균교치료전유개선（P＜0．05），치료후간예조교상규치료조폐공능개선명현，차이유현저성（P＜0．05）；치료후간예조교상규치료조 IFN-γ、IL-12승고명현，IL-4하강경명현，차이유통계학의의（P＜0．05）。결론잡개묘통과조절효천환자Thl/Th2비례실형개선폐공능。
Objective To explore the mechanism of BCG on regulating T cell balance and improve the inflammatory airway. Methods 208 asthmatic patients were divided into BCG intervention group and conventional group randomly.Lung function indicators and IL-4,IFN-γand IL-1 2 levels were detected before and after the treatment. Results After 6 months treatment, both groups had great improvement in pulmonary function test,however interventional group showed better than conventional group (P <0.05 ). After treatment plasma IL-4 level was decreased,but levels of IFN-γand IL-1 2 was increased.there was a significant difference(P<0.05).After treatment in the interventional group plasma IL-4 level was lower than that of conventional group(P<0.05);IFN-γand IL-1 2 levels were higher than that of conventional group(P<0.05 ). Conclusion BCG can regulate the Th1 /Th2 imblanace and improve pulmonary function of bronchial asthma.