CAJ | 학술논문

目的：研究碱性成纤维细胞生长因子在鼻咽癌中的表达，探讨它与鼻咽癌的增生、浸润及转移的关系。方法在26例鼻咽癌及相应癌旁组织和10例正常鼻咽部黏膜组织中，应用 RT-PCR和免疫组织化学方法检测碱性成纤维细胞生长因子mRNA和蛋白质的表达。结果碱性成纤维细胞生长因子在鼻咽癌组织中高表达，在正常鼻咽部黏膜中低表达，差异具有统计学意义（P＜0．01）。结论碱性成纤维细胞生长因子与鼻咽癌的生长、浸润及转移有密切关系。
목적：연구감성성섬유세포생장인자재비인암중적표체，탐토타여비인암적증생、침윤급전이적관계。방법재26례비인암급상응암방조직화10례정상비인부점막조직중，응용 RT-PCR화면역조직화학방법검측감성성섬유세포생장인자mRNA화단백질적표체。결과감성성섬유세포생장인자재비인암조직중고표체，재정상비인부점막중저표체，차이구유통계학의의（P＜0．01）。결론감성성섬유세포생장인자여비인암적생장、침윤급전이유밀절관계。
Objective To study the expressions of basic fibroblast growth factor (bFGF ) in nasopharyngeal carcinoma (NPC ) and its significance. Methods In this study,we investigated the expression level of bFGF in twenty-six NPC and tissues adjacent to tumor and ten normal nasopharyngeal mucous membrane using techniques of semi-quantify RT-PCR and immunohistochemistry. Results It was showed that the expression level of bFGF was significantly increased in NPC as compared with the normal nasopharyngeal mucous membrane (P<0.01 ). Conclusion These data raise the possibility that bFGF may play key roles in the growth,invasion and metastasis of NPC.