CAJ | 학술논문

目的：观察虫草胃舒康（CCWSK）对急性炎症模型的影响，探讨虫草胃舒康的抗炎作用。方法选择昆明种小鼠60只，雄性Wistar大鼠50只，随机分为5组，模型组、阳性对照组（25％）、虫草胃舒康低、中、高3剂量组（3．10％、6．25％、12．5％，小鼠灌胃0．2 mL/10 g，大鼠灌胃1．0 mL/100 g）。分别复制二甲苯致小鼠耳廓肿胀模型，蛋清致大鼠足跖肿胀模型。比较用药前后动物组织肿胀的变化。结果 CCWSK高剂量组对二甲苯致小鼠耳肿胀有抑制作用，其肿胀度降低，为4．18±0．66，与模型组比较 P＜0．05，有显著性差异。肿胀抑制率高剂量组为49．81％；CCWSK中剂量组和高剂量组对蛋清致大鼠足跖肿胀有抑制作用，肿胀度分别为0．77±0．38、0．73±0.12，与模型组比较P＜0．05，有显著性差异。结论虫草胃舒康对大鼠、小鼠的急性炎症具有一定的抗炎作用。
목적：관찰충초위서강（CCWSK）대급성염증모형적영향，탐토충초위서강적항염작용。방법선택곤명충소서60지，웅성Wistar대서50지，수궤분위5조，모형조、양성대조조（25％）、충초위서강저、중、고3제량조（3．10％、6．25％、12．5％，소서관위0．2 mL/10 g，대서관위1．0 mL/100 g）。분별복제이갑분치소서이곽종창모형，단청치대서족척종창모형。비교용약전후동물조직종창적변화。결과 CCWSK고제량조대이갑분치소서이종창유억제작용，기종창도강저，위4．18±0．66，여모형조비교 P＜0．05，유현저성차이。종창억제솔고제량조위49．81％；CCWSK중제량조화고제량조대단청치대서족척종창유억제작용，종창도분별위0．77±0．38、0．73±0.12，여모형조비교P＜0．05，유현저성차이。결론충초위서강대대서、소서적급성염증구유일정적항염작용。
Objective To study the effect of CCWSK on acute inflammation. Methods 60 kunming mice,50 SD rats,were randomly divided into 5 groups,model group,positive control group (25%), CCWSK low-dose group (3.1 0%),middle-dose group (6.25%)and high-dose group (1 2.5%),mice were given by intragastric 0.2 mL/1 0 g,rats were given by intragastric 1 .0 mL/1 00 g.Each groups of rats or mice were given by intragastric a certain dose of solution for 5 days,individually,one time per day;At fifth day,copy the model of mouse auricle swelling induced by xylene respectively,egg white rats foot metatarsus swelling model.Compare medication before and after the changes in the animal tissue swelling. Results CCWSK high-dose group had inhibitory effect on mouse ear swelling induced by xylene,reduced its swelling degree(4.1 8 ±0.66 ),compared with model group (P <0.05 ),there was significant difference.The inhibition rate of high-dose group was 49 .81%;CCWSK middle-dose group and high-dose group of rats had the inhibition induced by egg white foot metatarsus swelling,swelling degree was 0.77 ±0.38,0.73 ±0.1 2. comparing with model group P<0.05,there was significant difference. Conclusion CCWSK has obvious anti-inflammatory effect.