辽宁师范大学学报（自然科学版）
遼寧師範大學學報（自然科學版）
료녕사범대학학보（자연과학판）
JOURNAL OF LIAONING NORMAL UNIVERSITY(NATURAL SCIENCE)
2014年
2期
238-245
,共8页
necroptosis%受体相互作用蛋白%信号通路%诱导死亡信号复合体
necroptosis%受體相互作用蛋白%信號通路%誘導死亡信號複閤體
necroptosis%수체상호작용단백%신호통로%유도사망신호복합체
necroptosis%receptor interacting protein%signaling pathway%necrosome
坏死在众多生理和病理进程中都扮演着重要的作用．最近，一种新型的被称为“necroptosis”的细胞坏死程序受到了人们的普遍关注．从形态学上来讲，necroptosis表现出和坏死相同的特征；然而，它却有自己独特的信号通路，这种通路需要受体相互作用蛋白激酶RIP1和RIP3的参与，形成诱导死亡信号复合体，从而促进细胞程序性坏死，但可以被necrostatins特异性地抑制．Necroptosis有助于免疫系统的调节，癌症的治疗以及多种压力下细胞的应答．本篇综述中我们将总结这种特殊的程序性死亡的信号通路、生物学效应和病理学意义．
壞死在衆多生理和病理進程中都扮縯著重要的作用．最近，一種新型的被稱為“necroptosis”的細胞壞死程序受到瞭人們的普遍關註．從形態學上來講，necroptosis錶現齣和壞死相同的特徵；然而，它卻有自己獨特的信號通路，這種通路需要受體相互作用蛋白激酶RIP1和RIP3的參與，形成誘導死亡信號複閤體，從而促進細胞程序性壞死，但可以被necrostatins特異性地抑製．Necroptosis有助于免疫繫統的調節，癌癥的治療以及多種壓力下細胞的應答．本篇綜述中我們將總結這種特殊的程序性死亡的信號通路、生物學效應和病理學意義．
배사재음다생리화병리진정중도분연착중요적작용．최근，일충신형적피칭위“necroptosis”적세포배사정서수도료인문적보편관주．종형태학상래강，necroptosis표현출화배사상동적특정；연이，타각유자기독특적신호통로，저충통로수요수체상호작용단백격매RIP1화RIP3적삼여，형성유도사망신호복합체，종이촉진세포정서성배사，단가이피necrostatins특이성지억제．Necroptosis유조우면역계통적조절，암증적치료이급다충압력하세포적응답．본편종술중아문장총결저충특수적정서성사망적신호통로、생물학효응화병이학의의．
Necrosis plays an important role in multiple physiological and pathological processes .Re-cently ,a relatively new form of necrosis has been characterized as “necroptosis” .Morphologically , necroptosis exhibits the same features as necrosis ;however ,necroptosis exhibits a unique signaling pathway that requires the involvement of receptor interaction protein kinase 1 and 3(RIP1 and RIP3) to form necrosome ,a complex that can promote programmed cell death .Necroptosis can be specifical-ly inhibited by necrostatins .Necroptosis has been found to contribute to the regulation of immune system ,cancer development as well as cellular responses to multiple stresses .In this review ,we will summarize the signaling pathway ,biological effects and pathological significance of the specific form of programmed cell death .
