CAJ | 학술논문

目的：探索人群华支睾吸虫病不同流行程度地区的防治化疗措施。方法选择广东省人群华支睾吸虫病高、中、低度流行区，分别设立干预组和对照组，干预组分别对3岁以上人群、重点人群和感染者实施阿苯达唑驱虫干预措施；对照组不采取任何措施。结果干预1年后，干预组人群华支睾吸虫感染率显著降低，高、中度和低度流行区分别下降了47.90%、86.52%和100%；肝脏B超异常率分别下降了26.50%、31.00%和100%；丙氨酸氨基转移酶异常率分别下降了48.70%、62.30%和100%，天冬氨酸氨基转移酶异常率分别下降了55.50%、39.90%和100%。对照组人群所有指标无下降趋势。结论人群华支睾吸虫病不同流行程度地区应采取不同的化疗措施。
목적：탐색인군화지고흡충병불동류행정도지구적방치화료조시。방법선택광동성인군화지고흡충병고、중、저도류행구，분별설립간예조화대조조，간예조분별대3세이상인군、중점인군화감염자실시아분체서구충간예조시；대조조불채취임하조시。결과간예1년후，간예조인군화지고흡충감염솔현저강저，고、중도화저도류행구분별하강료47.90%、86.52%화100%；간장B초이상솔분별하강료26.50%、31.00%화100%；병안산안기전이매이상솔분별하강료48.70%、62.30%화100%，천동안산안기전이매이상솔분별하강료55.50%、39.90%화100%。대조조인군소유지표무하강추세。결론인군화지고흡충병불동류행정도지구응채취불동적화료조시。
Objective To explore the suitable chemotherapy measures in different Clonorchis sinensis infectiosity endemic ar-eas. Methods The interventional groups and control groups were set up in the heavy,moderate and light C. sinensis infectiosity areas in Guangdong Province,respectively. In the intervention groups,the chemotherapy was administered among all the residents aged above 3 years in the heavy endemic areas,the chemotherapy was given among the focus populations in the moderate endemic areas,and the chemotherapy was administered among the residents infected with C. sinensis confirmed by stool examinations in the light endemic areas. No measures were carried out in the control groups. Results One year after the interventions,the C. sinensis infection rates of the interventional groups decreased by 47.90%,86.52%and 100%,the abnormal rates of liver B ultrasonic ex-aminations decreased by 26.50%,31.00%and 100%,the ALT abnormal rates decreased by 48.70%,62.30%and 100%,and the AST abnormal rates decreased by 55.50%,39.90% and 100% in the heavy,moderate and light endemic areas,respectively. There was no decreasing trend of above-mentioned indexes in the control groups. Conclusion In the different C. sinensis infectios-ity endemic areas,the different chemotherapy measures should be carried out.