中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
11期
1144-1147
,共4页
代谢综合征%瘦素%胰岛素抵抗指数
代謝綜閤徵%瘦素%胰島素牴抗指數
대사종합정%수소%이도소저항지수
Metabolic syndrome%Leptin%Insulin resistance index
目的 探讨蒙古族、汉族代谢综合征(MS)患者瘦素水平的差异及其相关影响因素分析.方法 根据MS的诊断标准,从健康体检人群中选取蒙古族、汉族MS患者291例,其中汉族MS患者146例(A组),蒙古族MS患者145例(B组).采用放射免疫方法检测血清瘦素,同时检测身高、体质量、血压、血糖、血脂、血尿酸(sUA)、胰岛素,并计算体质量指数和胰岛素抵抗指数.结果 B组的空腹血糖(FPG)[(6.2±1.5) mmol/L]、低密度脂蛋白胆固醇(LDL-C)[(3.1 ±0.8) mmol/L]、瘦素[(4.3±2.0)μg/L]、胰岛素[(22.4±16.0)mU/L]以及胰岛素抵抗指数[(6.5±0.5)]和A组的FPG[(6.7±1.7)mmol/L]、LDL-C[(2.7±0.7)mmol/L]、瘦素[(3.4±1.5)μg/L]、胰岛素[(18.8±14.0) mU/L]和胰岛素抵抗指数[(4.7±3.6)]相比差异有统计学意义(t =2.04、2.84、3.47、2.18、4.82,P＜0.01或P＜0.05).B组的年龄[(46.9±9.8)岁]、收缩压(SBP)[(146.8±17.0) mm Hg]、舒张压(DBP)[(90.5±11.6) mm Hg]、体质量指数[(27.4±2.9)kg/m2]、总胆固醇(TC)[(5.5±1.0) mmol/L]、甘油三酯(TG)[(2.3 ±1.4) mmol/L]、高密度脂蛋白胆固醇(HDL-C)[(1.3±0.3)mmol/L]和sUA[(320.7±93.6)μmol/L]和A组的年龄[(46.3±8.4)岁]、SBP[(149.1±19.2)mm Hg]、DBP[(92.5±13.1)mmHg]、体质量指数[(27.9±3.2) kg/m2]、TC[(5.5±0.9)mmol/L]、TG[(2.3±1.4) mmol/L]、HDL-C[(1.2±0.4) mmol/L]和sUA[(308.7±86.9)μmol/L]相比差异无统计学意义(t=0.47、0.90、1.15、1.15、0、0、1.00、0.94,P均＞0.05).B组瘦素水平的升高与空腹血糖、胰岛素和胰岛素抵抗指数相关(r =0.108、0.146、0.183,P均＜0.05),体质量指数、胰岛素、胰岛素抵抗指数是血清瘦素水平升高的影响因素.结论 蒙古族MS患者瘦素水平与空腹血糖、胰岛素和胰岛素抵抗指数相关,瘦素在MS的形成与发展中起重要作用.
目的 探討矇古族、漢族代謝綜閤徵(MS)患者瘦素水平的差異及其相關影響因素分析.方法 根據MS的診斷標準,從健康體檢人群中選取矇古族、漢族MS患者291例,其中漢族MS患者146例(A組),矇古族MS患者145例(B組).採用放射免疫方法檢測血清瘦素,同時檢測身高、體質量、血壓、血糖、血脂、血尿痠(sUA)、胰島素,併計算體質量指數和胰島素牴抗指數.結果 B組的空腹血糖(FPG)[(6.2±1.5) mmol/L]、低密度脂蛋白膽固醇(LDL-C)[(3.1 ±0.8) mmol/L]、瘦素[(4.3±2.0)μg/L]、胰島素[(22.4±16.0)mU/L]以及胰島素牴抗指數[(6.5±0.5)]和A組的FPG[(6.7±1.7)mmol/L]、LDL-C[(2.7±0.7)mmol/L]、瘦素[(3.4±1.5)μg/L]、胰島素[(18.8±14.0) mU/L]和胰島素牴抗指數[(4.7±3.6)]相比差異有統計學意義(t =2.04、2.84、3.47、2.18、4.82,P＜0.01或P＜0.05).B組的年齡[(46.9±9.8)歲]、收縮壓(SBP)[(146.8±17.0) mm Hg]、舒張壓(DBP)[(90.5±11.6) mm Hg]、體質量指數[(27.4±2.9)kg/m2]、總膽固醇(TC)[(5.5±1.0) mmol/L]、甘油三酯(TG)[(2.3 ±1.4) mmol/L]、高密度脂蛋白膽固醇(HDL-C)[(1.3±0.3)mmol/L]和sUA[(320.7±93.6)μmol/L]和A組的年齡[(46.3±8.4)歲]、SBP[(149.1±19.2)mm Hg]、DBP[(92.5±13.1)mmHg]、體質量指數[(27.9±3.2) kg/m2]、TC[(5.5±0.9)mmol/L]、TG[(2.3±1.4) mmol/L]、HDL-C[(1.2±0.4) mmol/L]和sUA[(308.7±86.9)μmol/L]相比差異無統計學意義(t=0.47、0.90、1.15、1.15、0、0、1.00、0.94,P均＞0.05).B組瘦素水平的升高與空腹血糖、胰島素和胰島素牴抗指數相關(r =0.108、0.146、0.183,P均＜0.05),體質量指數、胰島素、胰島素牴抗指數是血清瘦素水平升高的影響因素.結論 矇古族MS患者瘦素水平與空腹血糖、胰島素和胰島素牴抗指數相關,瘦素在MS的形成與髮展中起重要作用.
목적 탐토몽고족、한족대사종합정(MS)환자수소수평적차이급기상관영향인소분석.방법 근거MS적진단표준,종건강체검인군중선취몽고족、한족MS환자291례,기중한족MS환자146례(A조),몽고족MS환자145례(B조).채용방사면역방법검측혈청수소,동시검측신고、체질량、혈압、혈당、혈지、혈뇨산(sUA)、이도소,병계산체질량지수화이도소저항지수.결과 B조적공복혈당(FPG)[(6.2±1.5) mmol/L]、저밀도지단백담고순(LDL-C)[(3.1 ±0.8) mmol/L]、수소[(4.3±2.0)μg/L]、이도소[(22.4±16.0)mU/L]이급이도소저항지수[(6.5±0.5)]화A조적FPG[(6.7±1.7)mmol/L]、LDL-C[(2.7±0.7)mmol/L]、수소[(3.4±1.5)μg/L]、이도소[(18.8±14.0) mU/L]화이도소저항지수[(4.7±3.6)]상비차이유통계학의의(t =2.04、2.84、3.47、2.18、4.82,P＜0.01혹P＜0.05).B조적년령[(46.9±9.8)세]、수축압(SBP)[(146.8±17.0) mm Hg]、서장압(DBP)[(90.5±11.6) mm Hg]、체질량지수[(27.4±2.9)kg/m2]、총담고순(TC)[(5.5±1.0) mmol/L]、감유삼지(TG)[(2.3 ±1.4) mmol/L]、고밀도지단백담고순(HDL-C)[(1.3±0.3)mmol/L]화sUA[(320.7±93.6)μmol/L]화A조적년령[(46.3±8.4)세]、SBP[(149.1±19.2)mm Hg]、DBP[(92.5±13.1)mmHg]、체질량지수[(27.9±3.2) kg/m2]、TC[(5.5±0.9)mmol/L]、TG[(2.3±1.4) mmol/L]、HDL-C[(1.2±0.4) mmol/L]화sUA[(308.7±86.9)μmol/L]상비차이무통계학의의(t=0.47、0.90、1.15、1.15、0、0、1.00、0.94,P균＞0.05).B조수소수평적승고여공복혈당、이도소화이도소저항지수상관(r =0.108、0.146、0.183,P균＜0.05),체질량지수、이도소、이도소저항지수시혈청수소수평승고적영향인소.결론 몽고족MS환자수소수평여공복혈당、이도소화이도소저항지수상관,수소재MS적형성여발전중기중요작용.
Objective To investigate the differences of leptin (LEP) between Mongol and Han population with metabolic syndrome (MS) and its related factors.Methods According to the diagnostic criterion of MS,291 people with MS were selected as subjects,of which,146 were Han nationality(A group) and 145 were Mongol(B group).Radioimmunoassay kit was used to measure the serum leptin level.At the same time,the indices including weight,height,blood pressure,blood glucose,blood lipid,Serum uric acid (sUA),insulin (Fins),body mass index (BMI) and insulin resistance index (HOMA-IR) were measured.Results The following indices in B group including fasting plasma glucose (FPG),Low-density lipoprotein cholesterol (LDL-C),leptin,blood insulin,insulin resistance index were (6.2 ± 1.5) mmol/L,(3.1 ± 0.8) mmol/L,(4.3 ± 2.0) μg/L,(22.4-± 16.0) mU/L and (6.5 ± 0.5) respectively,significantly differed from that of A group ((6.7 ±1.7) mmol/L,(2.7 ±0.7) mmol/L,(3.4 ± 1.5) μg/L,(18.8 ±14.0) mU/L,(4.7 ±3.6)respectively;t =2.04,2.84,3.47,2.18,4.82 ;P ＜ 0.01 or P ＜ 0.05).There was no significant difference in terms of age((46.9 ±9.8) vs.(46.3 ± 8.4)),systolic blood pressure (SBP) ((146.8 ± 17.0) mm Hg vs.(149.1 ±19.2) mm Hg),diastolic blood pressure (DBP) ((90.5 ± 11.6) mm Hg vs.(92.5 ± 13.1) mm Hg),BMI ((27.4 ± 2.9) kg/m2 vs.(27.9 ± 3.2) kg/m2),total cholesterol (TC) ((5.5 ± 1.0) mmol/L vs.(5.5 ±0.9) mmol/L),triacylglycerol (TG) ((2.3 ± 1.4) mmol/L vs.(2.3 ± 1.4) mmol/L),high density lipid cholesterol (HDL-C) ((1.3 ±0.3) mmol/L vs.(1.2 ±0.4) mmol/L),and sUA (((320.7 ±93.6)μmol/L) vs.(308.7 ±86.9) μmol/L) between the patients with metabolic syndrome in Mongol population and in Han population(t =0.47,0.90,1.15,1.15,0,0,1.00,0.94 respectively,P ＞ 0.05).The increase of leptin level in the patients with metabolic syndrome in B group was associated with blood glucose,blood insulin and insulin resistance index (r =0.108,0.146,0.183 ; P ＜ 0.05).BMI,blood insulin and insulin resistance index may be the factors due to the higher of serum leptin levels.Conclusion The serum leptin of patients with metabolic syndrome in Mongol population are correlated with blood glucose,blood insulin and insulin resistance index,which plays an important role in the development of metabolic syndrome.
