CAJ | 학술논문

特异性环氧化酶2(Cyclooxygenase-2,COX-2)抑制剂为COX-2的高选择性抑制物,是一类非甾体抗炎药,具有抗炎镇痛作用,可以改善风湿性疾病的炎性症状并可缓解疼痛。近年来研究发现,特异性COX-2抑制剂会增加心血管疾病的发生率,在心肌肥厚中的作用也受到广泛关注。因此本文对特异性COX-2抑制剂在心肌肥厚中作用作一综述。
특이성배양화매2(Cyclooxygenase-2,COX-2)억제제위COX-2적고선택성억제물,시일류비치체항염약,구유항염진통작용,가이개선풍습성질병적염성증상병가완해동통。근년래연구발현,특이성COX-2억제제회증가심혈관질병적발생솔,재심기비후중적작용야수도엄범관주。인차본문대특이성COX-2억제제재심기비후중작용작일종술。
Cyclooxygenase 2 ( Cyclooxygenase-2 , COX-2 ) inhibitor is highly selective COX-2 inhibitors and a kind of non-steroidal anti-inflammatory drugs. This kind of drugs can reduce inflammation,ease pain and improve the symptoms of Rheumatic diseases. Recent studies have found that COX-2 inhibitors may increase the rate of cardiovascular disease,thus the influence of these drugs on cardiac hypertrophy has also been paid wide spread attention. Therefore in this article we have a review to explore the role of COX-2 inhibitors in cardiac hypertrophy.