内蒙古医科大学学报
內矇古醫科大學學報
내몽고의과대학학보
Journal of Inner Mongolia Medical University
2014年
3期
243-245
,共3页
野菊花%软膏剂%急性毒性%长期毒性
野菊花%軟膏劑%急性毒性%長期毒性
야국화%연고제%급성독성%장기독성
wild chrysanthemum%ointments%acute toxicity%long-term toxicity
目的：为使野菊花软膏剂的应用更安全、合理。方法：将野菊花软膏剂分为高、中、低三个剂量组(按其浓度为0.15 g/mL、0.10 g/mL、0.05 g/mL)给药。用于大鼠皮肤，同时做空白基质对照，测定其软膏剂对大鼠皮肤的急性毒性、长期毒性试验。结果：各给药剂量组和空白基质对照组对大鼠的体重增长、血液常规、生化指标及病理检查等项指标的测定均无显著性差异(P>0.05)。结论：野菊花软膏剂长期连续经皮肤给药对试验大鼠没有的毒性作用，本试验为野菊花的临床安全用药提供实验依据。
目的：為使野菊花軟膏劑的應用更安全、閤理。方法：將野菊花軟膏劑分為高、中、低三箇劑量組(按其濃度為0.15 g/mL、0.10 g/mL、0.05 g/mL)給藥。用于大鼠皮膚，同時做空白基質對照，測定其軟膏劑對大鼠皮膚的急性毒性、長期毒性試驗。結果：各給藥劑量組和空白基質對照組對大鼠的體重增長、血液常規、生化指標及病理檢查等項指標的測定均無顯著性差異(P>0.05)。結論：野菊花軟膏劑長期連續經皮膚給藥對試驗大鼠沒有的毒性作用，本試驗為野菊花的臨床安全用藥提供實驗依據。
목적：위사야국화연고제적응용경안전、합리。방법：장야국화연고제분위고、중、저삼개제량조(안기농도위0.15 g/mL、0.10 g/mL、0.05 g/mL)급약。용우대서피부，동시주공백기질대조，측정기연고제대대서피부적급성독성、장기독성시험。결과：각급약제량조화공백기질대조조대대서적체중증장、혈액상규、생화지표급병리검사등항지표적측정균무현저성차이(P>0.05)。결론：야국화연고제장기련속경피부급약대시험대서몰유적독성작용，본시험위야국화적림상안전용약제공실험의거。
Objective:In order to use wild chrysanthemum ointments safely and reasonable. Methods:The Wister rats for experimental study were divided into four groups:high、medium、low dose groups and base control group,according to different items to study acute toxicity of skin,long-term toxicity experiment,etc. Results:The results showed no significant statistical difference between each dose group and the base control group tests of body weight and blood as well as biochemical examination for rats(P>0. 05). Conclusion:Long-term use of wild chrysanthemum ointments has no toxicity to rats.
