CAJ | 학술논문

目的：探讨急性冠脉综合征（ACS）患者血清P-选择素、低密度脂蛋白胆固醇（LDL-C）水平的变化及临床意义。方法采用自动生化分析仪检测80例ACS患者（ACS组）、80例稳定性心绞痛患者（SAP组）和80例健康体检者（正常对照组）血清LDL-C水平，使用自动生化分析仪、采用酶联免疫分析法检测3组血清P-选择素水平。结果ACS组、SAP组血清P-选择素、LDL水平均明显高于正常对照组（P＜0.05或P＜0.01），ACS组血清P-选择素水平明显高于SAP组（P＜0.05），ACS组血清LDL水平与SAP组比较差异无统计学意义（P＞0.05）。相关分析结果显示，ACS组血清P-选择素水平与血清LDL-C水平呈正相关（r=0.349，P＜0.01）。结论检测ACS患者血清P-选择素、LDL-C水平的变化对ACS的发生发展均具有重要的临床意义，血清P-选择素浓度升高可以作为ACS发生的预测指标。
목적：탐토급성관맥종합정（ACS）환자혈청P-선택소、저밀도지단백담고순（LDL-C）수평적변화급림상의의。방법채용자동생화분석의검측80례ACS환자（ACS조）、80례은정성심교통환자（SAP조）화80례건강체검자（정상대조조）혈청LDL-C수평，사용자동생화분석의、채용매련면역분석법검측3조혈청P-선택소수평。결과ACS조、SAP조혈청P-선택소、LDL수평균명현고우정상대조조（P＜0.05혹P＜0.01），ACS조혈청P-선택소수평명현고우SAP조（P＜0.05），ACS조혈청LDL수평여SAP조비교차이무통계학의의（P＞0.05）。상관분석결과현시，ACS조혈청P-선택소수평여혈청LDL-C수평정정상관（r=0.349，P＜0.01）。결론검측ACS환자혈청P-선택소、LDL-C수평적변화대ACS적발생발전균구유중요적림상의의，혈청P-선택소농도승고가이작위ACS발생적예측지표。
Objective To investigate the changes in serum P-selectin and low density lipoprotein cholesterol (LDL-C) concentrations and their significance in patients with acute coronary syndrome (ACS).Methods Automatic biochemical analyzer and ELISA method were used to measure the serum levels of LDL-C and P-selectin in 80 patients with ACS (ACS group),80 patients with stable angina pectoris(SAP group)and 80 healthy subjects(control group). Results Compared with control group, le-vels of P-selectin and LDL-C significantly increased in ACS group and SAP group(P<0.05 or P<0.01). Compared with SAP group, levels of P-selectin significantly increased in ACS group(P<0.05).There were no significant differences in LDL-C levels between SAP group and ACS group (P>0.05). P-selectin levels were positively correlated with LDL-C levels in ACS group (r=0.349, P<0.01).Conclusion Changes in serum P-selectin and LDL-C levels have important clinical significance in the occurrence and development of ACS. The increase in P-selectin levels can be used as the predictive index for ACS.