实用中医药杂志
實用中醫藥雜誌
실용중의약잡지
JOURNAL OF PRACTICAL TRADITIONAL CHINESE MEDICINE
2014年
5期
385-385,386
,共2页
苜蓿总皂苷%小鼠%降血脂
苜蓿總皂苷%小鼠%降血脂
목숙총조감%소서%강혈지
Total saponins from Medicago sativa L.%mice%hypolipidemic effect
目的：观察苜蓿总皂苷对高脂血症小鼠血清血脂水平的影响。方法：采用高脂乳剂灌胃的方法建立高脂血症小鼠模型，分为苜蓿总皂苷高、中、低剂量组（1g/kg、0.5g/kg、0.25g/kg），阳性组（绞股蓝总苷片80 mg/kg），模型组，另设正常组，每组10只。灌胃给药，连续40天，各组取血清测定TCH、TG、HDL-C和LDL-C的含量。结果：苜蓿总皂苷高、中剂量组高脂血症小鼠的血清TCH、TG、LDL-C水平均明显下降，HDL-C水平明显上升，与模型组比较有统计学意义（P＜0.05或P＜0.01）。结论：苜蓿总皂苷有良好的降血脂作用。
目的：觀察苜蓿總皂苷對高脂血癥小鼠血清血脂水平的影響。方法：採用高脂乳劑灌胃的方法建立高脂血癥小鼠模型，分為苜蓿總皂苷高、中、低劑量組（1g/kg、0.5g/kg、0.25g/kg），暘性組（絞股藍總苷片80 mg/kg），模型組，另設正常組，每組10隻。灌胃給藥，連續40天，各組取血清測定TCH、TG、HDL-C和LDL-C的含量。結果：苜蓿總皂苷高、中劑量組高脂血癥小鼠的血清TCH、TG、LDL-C水平均明顯下降，HDL-C水平明顯上升，與模型組比較有統計學意義（P＜0.05或P＜0.01）。結論：苜蓿總皂苷有良好的降血脂作用。
목적：관찰목숙총조감대고지혈증소서혈청혈지수평적영향。방법：채용고지유제관위적방법건립고지혈증소서모형，분위목숙총조감고、중、저제량조（1g/kg、0.5g/kg、0.25g/kg），양성조（교고람총감편80 mg/kg），모형조，령설정상조，매조10지。관위급약，련속40천，각조취혈청측정TCH、TG、HDL-C화LDL-C적함량。결과：목숙총조감고、중제량조고지혈증소서적혈청TCH、TG、LDL-C수평균명현하강，HDL-C수평명현상승，여모형조비교유통계학의의（P＜0.05혹P＜0.01）。결론：목숙총조감유량호적강혈지작용。
Objective:To investigate the hypolipidemic effect of total saponins from Medicago sativa L.(TSM) on mice with hyperlipidemia.Methods:Model of hyperlipidemia was established by administration of high-fat diet for 40 days. Sixty mice were randomly divided into six groups (n=10) including positive (80mg/kg),model,normal control and three TSM groups at the doses of(1g/kg、0.5g/kg、0.25g/kg),respectively.After 40 days of TSM administration treatment,the levels of serum TCH,TG,HDL-C and LDL-C in mice with hyperlipidemia were evaluated by spectrophotometric method. Results:TSM administration could reduce the levels of serum TCH,TG and LDL-C,and increase that of HDL-C in mice with hyperlipidemia,which had a significant difference compared to the model control group (P<0.05 or P<0.01).Conclusion:TSM may have a good hypolipidemic effect.
