实用中医药杂志
實用中醫藥雜誌
실용중의약잡지
JOURNAL OF PRACTICAL TRADITIONAL CHINESE MEDICINE
2014年
5期
379-380,381
,共3页
脓毒症%益气活血解毒法%白介素-1β%氨基末端脑利钠肽前体
膿毒癥%益氣活血解毒法%白介素-1β%氨基末耑腦利鈉肽前體
농독증%익기활혈해독법%백개소-1β%안기말단뇌리납태전체
sepsis%qi-boosting blood-quickening detoxicating therapy%IL-1β%NT-proBNP
目的：观察益气活血解毒法对脓毒症白介素-1β（IL-1β）及氨基末端脑利钠肽前体（NT-proBNP）水平的影响。方法：60例随机分为治疗组30例和对照组30例，两组均给予常规西医治疗，治疗组加用参麦注射液、丹参酮ⅡA磺酸钠注射液静滴和热毒清口服液口服或鼻饲，两组疗程均为7天。两组分别于治疗前及治疗7天进行急性生理学与慢性健康状况评分系统（APACHEⅡ）评分，比较血清白介素-1β（IL-1β）和血浆氨基末端脑利钠肽前体（NT-proBNP）的变化及临床疗效。结果：治疗7天后，治疗组和对照组APACHE-Ⅱ分值、IL-1β、NT-proBNP水平均改善（P＜0.05），治疗组改善更为明显（P＜0.05）；治疗组总有效率93.3%，对照组总有效率73.3%，两组比较有统计学意义（P＜0.05）。结论：在西医治疗基础上用益气活血解毒法治疗脓毒症可抑制炎症因子，改善机体心肌抑制状况，有更好的治疗效果。
目的：觀察益氣活血解毒法對膿毒癥白介素-1β（IL-1β）及氨基末耑腦利鈉肽前體（NT-proBNP）水平的影響。方法：60例隨機分為治療組30例和對照組30例，兩組均給予常規西醫治療，治療組加用參麥註射液、丹參酮ⅡA磺痠鈉註射液靜滴和熱毒清口服液口服或鼻飼，兩組療程均為7天。兩組分彆于治療前及治療7天進行急性生理學與慢性健康狀況評分繫統（APACHEⅡ）評分，比較血清白介素-1β（IL-1β）和血漿氨基末耑腦利鈉肽前體（NT-proBNP）的變化及臨床療效。結果：治療7天後，治療組和對照組APACHE-Ⅱ分值、IL-1β、NT-proBNP水平均改善（P＜0.05），治療組改善更為明顯（P＜0.05）；治療組總有效率93.3%，對照組總有效率73.3%，兩組比較有統計學意義（P＜0.05）。結論：在西醫治療基礎上用益氣活血解毒法治療膿毒癥可抑製炎癥因子，改善機體心肌抑製狀況，有更好的治療效果。
목적：관찰익기활혈해독법대농독증백개소-1β（IL-1β）급안기말단뇌리납태전체（NT-proBNP）수평적영향。방법：60례수궤분위치료조30례화대조조30례，량조균급여상규서의치료，치료조가용삼맥주사액、단삼동ⅡA광산납주사액정적화열독청구복액구복혹비사，량조료정균위7천。량조분별우치료전급치료7천진행급성생이학여만성건강상황평분계통（APACHEⅡ）평분，비교혈청백개소-1β（IL-1β）화혈장안기말단뇌리납태전체（NT-proBNP）적변화급림상료효。결과：치료7천후，치료조화대조조APACHE-Ⅱ분치、IL-1β、NT-proBNP수평균개선（P＜0.05），치료조개선경위명현（P＜0.05）；치료조총유효솔93.3%，대조조총유효솔73.3%，량조비교유통계학의의（P＜0.05）。결론：재서의치료기출상용익기활혈해독법치료농독증가억제염증인자，개선궤체심기억제상황，유경호적치료효과。
Objective:To observe the clinical therapeutic effects of qi-boosting blood-quickening detoxicating therapy on Effects of IL-1βand NT-proBNP in patients with sepsis.Methods:60 cases were diagnosed as sepsis with Qi deficiency and blood stasis heat toxin filled type patients were randomLy divided into the the treatment group (n=30) and the control group (n=30).The general therapy of the two groups was the same,the treatment group were received Shen Mai injection,Sodium TanshinoneⅡAsilate injection and Reduqing oral liquid on the basis of the general therapy.Course of treatment was 7 days.Before and after seven days treatment,two groups were estimated separately on Traditional Chinese medical scores and acute physiology and chronic health evaluationⅡ(APACHE-Ⅱ),the changes of serum IL-1β,NT-proBNP and the clinical efficacy were compared in both groups.Results:APACHE-Ⅱscores and the serum IL-1β,NT-proBNP levels in both groups after treatment were improved obviously(P<0.05),the treatment group were more apparent(P<0.05);The efficiency was 93.3%in the treatment group and the control group was 73.3%,the two groups have a significant difference (P<0.05).Conclusion:The method of qi-boosting blood-quickening detoxicating have a better therapeutic effect by treating sepsis,inhibiting inflammatory factors and improving myocardial depression status.
