蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
5期
643-645
,共3页
伍宏兵%王金萍%许红强%陈晓艺%常丽娜%李保启
伍宏兵%王金萍%許紅彊%陳曉藝%常麗娜%李保啟
오굉병%왕금평%허홍강%진효예%상려나%리보계
乙型肝炎%声触诊组织定量%剪切波速%肝纤维化
乙型肝炎%聲觸診組織定量%剪切波速%肝纖維化
을형간염%성촉진조직정량%전절파속%간섬유화
hepatisis B%virtual touch quantification%shear wave velocity%liver fibrosis
目的：探讨声触诊组织定量技术对慢性乙型肝炎肝纤维化程度的诊断价值。方法：使用ACUSON S2000型彩色多谱勒超声诊断仪,测量96例慢性乙型肝炎患者和30名正常对照组的肝脏剪切波速。根据肝穿刺活检病理学肝纤维化分期对96例患者进行分组,运用受试者工作特征曲线初步划分不同肝纤维化程度剪切波速范围,并将剪切波速与病理结果进行相关性分析。结果：除对照组与肝纤维化S0期和S1期以及S0期与S1期之间的剪切波速差异无统计学意义(P>0.05)外,其余各组间剪切波速差异均有统计学意义(P<0.01)；以1.38 m/s、1.74 m/s、2.19 m/s、2.53 m/s作为诊断S≥1,S≥2,S≥3,S=4的受试者工作特征曲线下面积分别为0.808、0.872、0.889、0.861,对应的诊断敏感性分别为75.8%、80.5%、79.2%、78.6%,特异性分别为77.3%、83.4%、84.1%、79.5%。肝脏剪切波速与纤维化分期、炎症分级间均呈正相关关系(P<0.05)。结论：声触诊组织定量技术是无创性评价慢性乙型肝炎肝纤维化分期诊断的新方法。
目的：探討聲觸診組織定量技術對慢性乙型肝炎肝纖維化程度的診斷價值。方法：使用ACUSON S2000型綵色多譜勒超聲診斷儀,測量96例慢性乙型肝炎患者和30名正常對照組的肝髒剪切波速。根據肝穿刺活檢病理學肝纖維化分期對96例患者進行分組,運用受試者工作特徵麯線初步劃分不同肝纖維化程度剪切波速範圍,併將剪切波速與病理結果進行相關性分析。結果：除對照組與肝纖維化S0期和S1期以及S0期與S1期之間的剪切波速差異無統計學意義(P>0.05)外,其餘各組間剪切波速差異均有統計學意義(P<0.01)；以1.38 m/s、1.74 m/s、2.19 m/s、2.53 m/s作為診斷S≥1,S≥2,S≥3,S=4的受試者工作特徵麯線下麵積分彆為0.808、0.872、0.889、0.861,對應的診斷敏感性分彆為75.8%、80.5%、79.2%、78.6%,特異性分彆為77.3%、83.4%、84.1%、79.5%。肝髒剪切波速與纖維化分期、炎癥分級間均呈正相關關繫(P<0.05)。結論：聲觸診組織定量技術是無創性評價慢性乙型肝炎肝纖維化分期診斷的新方法。
목적：탐토성촉진조직정량기술대만성을형간염간섬유화정도적진단개치。방법：사용ACUSON S2000형채색다보륵초성진단의,측량96례만성을형간염환자화30명정상대조조적간장전절파속。근거간천자활검병이학간섬유화분기대96례환자진행분조,운용수시자공작특정곡선초보화분불동간섬유화정도전절파속범위,병장전절파속여병리결과진행상관성분석。결과：제대조조여간섬유화S0기화S1기이급S0기여S1기지간적전절파속차이무통계학의의(P>0.05)외,기여각조간전절파속차이균유통계학의의(P<0.01)；이1.38 m/s、1.74 m/s、2.19 m/s、2.53 m/s작위진단S≥1,S≥2,S≥3,S=4적수시자공작특정곡선하면적분별위0.808、0.872、0.889、0.861,대응적진단민감성분별위75.8%、80.5%、79.2%、78.6%,특이성분별위77.3%、83.4%、84.1%、79.5%。간장전절파속여섬유화분기、염증분급간균정정상관관계(P<0.05)。결론：성촉진조직정량기술시무창성평개만성을형간염간섬유화분기진단적신방법。
Objective:To study the diagnostic value of virtual touch quantification technology in liver fibrosis grades induced by chronic hepatisis B. Methods:The study subjects were performed the measurements of liver shear wave velocity by using a ultrasonic instrument named ACUSON S2000,and were composed with 30 normal control and 96 patients with chronic hepatitis B. The cutoff values of shear wave velocity of different liver fibrosis stages were detected and the correlations between shear wave velocity and pathological grades of the liver were analyzed. Results:The results showed that except for the shear wave velocity values among the control group and liver fibrosis stage S0 and stage S1 groups,and between liver fibrosis stage S0 and stage S1 groups,there were significant differences about the shear wave velocity values between other groups(P <0. 01). Using the cutoff values of 1. 38m/ s,1. 74 m/ s,2. 19 m/ s and 2. 53m/ s for diagnosis of S≥1,S≥2,S≥3 and S = 4,the corresponding areas under receiver operating characteristic were 0. 808,0. 8723,0. 889 and 0. 861 respectively,and the corresponding sensibilities were 75. 8%,80. 5%,79. 2%, 78. 6%,the specificities were 77. 3%,83. 4%,84. 1%,79. 5% respectively. The significant positive correlations were found between the shear wave velocity values and the grade of fibrosis and inflammation(P < 0. 05). Conclusions:Virtual tuoch quantification technology is a new non-invasive method to evaluate liver fibrosis grades induced by chronic hepatisis B.
