CAJ | 학술논문

目的：探讨单磷酸阿糖腺苷治疗儿童传染性单核细胞增多症( IM)的效果。方法：165例确诊为IM患儿,按照治疗方案分为阿糖腺苷组92例和更昔洛韦组73例,阿糖腺苷组静脉滴注单磷酸阿糖腺苷注射液10 mg/kg,1次/天,总疗程10~14 d；更昔洛韦组静脉滴注更昔洛韦注射液10 mg/kg,2次/天,7 d 后改为5 mg/kg,1次/天,总疗程10~14 d。观察2组急性期热程、咽峡炎改善时间、肝脾淋巴结回缩时间、异型淋巴细胞数恢复至正常时间并比较2组疗效。结果：2组在急性期热程、咽峡炎的改善、肝脾淋巴结回缩及异型淋巴细胞计数恢复至正常时间差异均无统计学意义(P>0.05)；2组总有效率差异亦无统计学意义( P>0.05)。结论：单磷酸阿糖腺苷可取得与更昔洛韦治疗儿童IM相同的效果。
목적：탐토단린산아당선감치료인동전염성단핵세포증다증( IM)적효과。방법：165례학진위IM환인,안조치료방안분위아당선감조92례화경석락위조73례,아당선감조정맥적주단린산아당선감주사액10 mg/kg,1차/천,총료정10~14 d；경석락위조정맥적주경석락위주사액10 mg/kg,2차/천,7 d 후개위5 mg/kg,1차/천,총료정10~14 d。관찰2조급성기열정、인협염개선시간、간비림파결회축시간、이형림파세포수회복지정상시간병비교2조료효。결과：2조재급성기열정、인협염적개선、간비림파결회축급이형림파세포계수회복지정상시간차이균무통계학의의(P>0.05)；2조총유효솔차이역무통계학의의( P>0.05)。결론：단린산아당선감가취득여경석락위치료인동IM상동적효과。
Objective:To explore the effects of vidarabine monophosphate in the treatment of infectious mononucleosis ( IM ) in children. Methods:One hundred and sixty-five children with IM were divided into vidarabine group 92 cases and ganciclovir group 73 cases according to their treatment protocol. The vidarabine group and ganciclovir group were treated with 10 mg/kg of vidarabine through intravenous drip once a day for 10 to 14 days and 10 mg/kg of ganciclovir through intravenous drip once 12 hours for 7 days, then 5 mg/kg once a day for 3 to 7 days, respectively. The fever course of acute phase, isthmopyra improvement time, hepatic and splenic lymph node retraction time and atypical lymphocyte recovery time in two groups were observed. The curative effects of two groups were analysed. Results:The differences of the fever course of acute phase, isthmopyra improvement time, hepatic and splenic lymph node retraction time and atypical lymphocyte recovery time between two groups were not statistical significances(P >0. 05). The difference of curative effect between two groups was not statistical significances(P >0. 05). Conclusions:The effect of vidarabine monophosphate in the treatment of IM in children is similar to ganciclovir.