CAJ | 학술논문

目的：观察α-硫辛酸治疗糖尿病神经源性膀胱( DNB)的临床疗效。方法：将39例DNB患者随机分为治疗组20例和对照组19例,2组均给予糖尿病基础治疗,其中治疗组还给予α-硫辛酸治疗2周,对比治疗前后2组患者膀胱残余尿量差异。结果：治疗2周后,治疗组和对照组患者膀胱残余尿量均较治疗前均减少(P<0.01和P<0.05),且治疗组治疗后膀胱残余尿明显少于对照组(P<0.01),治疗组有效率明显高于对照组(P=0.00)。结论：α-硫辛酸治疗DNB效果显著,值得临床推广应用。
목적：관찰α-류신산치료당뇨병신경원성방광( DNB)적림상료효。방법：장39례DNB환자수궤분위치료조20례화대조조19례,2조균급여당뇨병기출치료,기중치료조환급여α-류신산치료2주,대비치료전후2조환자방광잔여뇨량차이。결과：치료2주후,치료조화대조조환자방광잔여뇨량균교치료전균감소(P<0.01화P<0.05),차치료조치료후방광잔여뇨명현소우대조조(P<0.01),치료조유효솔명현고우대조조(P=0.00)。결론：α-류신산치료DNB효과현저,치득림상추엄응용。
Objective:To investigate the effect of α-lipoic acid on diabetic neurogenic bladder( DNB) . Methods:Thirty-nine patients with DNB were randomly divided into treatment group(n=20) and control group(n=19). Both groups received the common therapy for diabetes,and the treatment group were administered α-lipoic acid at the dose of for a 2-week course in addition. The changes of the patients′residual urine volume were compared between the two groups. Results:After 2 weeks of medication,the treatment group and the control group both showed a decreased residual urine volume as compared with that before the treatment(P<0. 01 and P<0. 05);the treatment group had a more obviously decreased residual urine volume than the control(P <0. 01). The total efficacy of the treatment group was significantly better than that of the control group(P=0. 00). Conclusions:α-lipoic acid can significantly decrease the residual urine volume in patients with DNB and is worthy to be popularized.