CAJ | 학술논문

目的：探讨乙型肝炎病毒（HBV ）感染与症状性颅内动脉粥样硬化性狭窄的相关性。方法选择症状性颅内动脉粥样硬化性狭窄患者152例为狭窄组，另选无颅内动脉粥样硬化性狭窄者152例为对照组。采用ELISA检测2组患者血清 HBV抗原及抗体。分析影响颅内动脉粥样硬化性狭窄的危险因素，并探讨HBV感染与颅内动脉粥样硬化性狭窄的关系。结果与对照组比较，狭窄组年龄、高血压、脑卒中或短暂性脑缺血发作、糖化血红蛋白水平明显升高（ P＜0．05）。狭窄组血清 HBV 阳性率为40．1％，对照组为18．4％，差异有统计学意义（ P＜0．01）。logistic多因素回归分析显示，排除危险因素影响后，HBV阳性为颅内动脉粥样硬化性狭窄的独立危险因素（OR＝2.261，95％ CI：1．149～4．448，P＜0．05）。结论 HBV感染可能是颅内动脉粥样硬化性狭窄的独立危险因素，积极干预HBV感染或许有助于预防颅内动脉粥样硬化性狭窄的发生。
목적：탐토을형간염병독（HBV ）감염여증상성로내동맥죽양경화성협착적상관성。방법선택증상성로내동맥죽양경화성협착환자152례위협착조，령선무로내동맥죽양경화성협착자152례위대조조。채용ELISA검측2조환자혈청 HBV항원급항체。분석영향로내동맥죽양경화성협착적위험인소，병탐토HBV감염여로내동맥죽양경화성협착적관계。결과여대조조비교，협착조년령、고혈압、뇌졸중혹단잠성뇌결혈발작、당화혈홍단백수평명현승고（ P＜0．05）。협착조혈청 HBV 양성솔위40．1％，대조조위18．4％，차이유통계학의의（ P＜0．01）。logistic다인소회귀분석현시，배제위험인소영향후，HBV양성위로내동맥죽양경화성협착적독립위험인소（OR＝2.261，95％ CI：1．149～4．448，P＜0．05）。결론 HBV감염가능시로내동맥죽양경화성협착적독립위험인소，적겁간예HBV감염혹허유조우예방로내동맥죽양경화성협착적발생。
Objective To study the association between HBV infection and symptomatic intracrani-al atherosclerotic stenosis .Methods One hundred and fifty-two patients with symptomatic in-tracranial atherosclerotic stenosis served as a stenosis group and 152 patients without symptomat-ic intracranial atherosclerotic stenosis served as a control group in this study .Their HBV serum antigens (HBsAg ,HBeAg) and antibodies (HBsAb ,HBcAb ,HBeAb) were detected by ELISA . The risk factors for intracranial atherosclerotic stenosis and the relation between HBV infection and intracranial atherosclerosis were analyzed .Results The age was older ,the incidence of hyper-tension and transient cerebral ischemia or ischemic stroke and the serum HbA 1c level were signif-icantly higher in stenosis group than in control group (P<0 .05) .The seroprevalence of HBV in-fection was significantly higher in stenosis group than in control group (40 .1% vs 18 .4% ,P<0.01) .Multivariate logistic regression analysis showed that HBV infection was an independent risk factor for intracranial atherosclerotic stenosis (OR= 2 .261 ,95% CI:1 .149 -4 .448 ,P<0.05) .Conclusion HBV infection is an independent risk factor for intracranial atherosclerotic stenosis .Its active intervention helps to prevent intracranial atherosclerotic stenosis .