中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
6期
617-619
,共3页
白细胞介素8%阿尔茨海默病%基因型%等位基因%疾病遗传易感性
白細胞介素8%阿爾茨海默病%基因型%等位基因%疾病遺傳易感性
백세포개소8%아이자해묵병%기인형%등위기인%질병유전역감성
interleukin-8%Alzheimer disease%genotype%alleles%genetic predisposition to disease
目的：探讨白细胞介素8（IL-8）基因-251A/T多态性与新疆汉族人群迟发性阿尔茨海默病（LOAD）遗传易感性的关系。方法选择老年患者80例为LOAD组，同期体检者80例为对照组。采用 PCR-RFLP检测IL-8基因-251A/T多态性分布。结果2组AA基因型分布及A等位基因频率比较，差异有统计学意义（16．3％ vs 7．5％， P＝0．035；41．3％ vs 27．5％，P＝0．010）。进一步分析显示，LOAD组A等位基因频率可能是LOAD的危险因素（OR＝1．851，95％ CI：1．159～2．957，P＝0．010）；AA基因型患LOAD的危险性是 TT 基因型的3．370倍（OR＝3.370，95％ CI：1．143～9．939，P＝0.023）；AT 基因型与 LOAD发病风险不相关（OR＝1．944，95％ CI：0．994～3.803，P＝0．051）。结论 IL-8基因-251A/T多态性与LOAD发病风险有一定关系。
目的：探討白細胞介素8（IL-8）基因-251A/T多態性與新疆漢族人群遲髮性阿爾茨海默病（LOAD）遺傳易感性的關繫。方法選擇老年患者80例為LOAD組，同期體檢者80例為對照組。採用 PCR-RFLP檢測IL-8基因-251A/T多態性分佈。結果2組AA基因型分佈及A等位基因頻率比較，差異有統計學意義（16．3％ vs 7．5％， P＝0．035；41．3％ vs 27．5％，P＝0．010）。進一步分析顯示，LOAD組A等位基因頻率可能是LOAD的危險因素（OR＝1．851，95％ CI：1．159～2．957，P＝0．010）；AA基因型患LOAD的危險性是 TT 基因型的3．370倍（OR＝3.370，95％ CI：1．143～9．939，P＝0.023）；AT 基因型與 LOAD髮病風險不相關（OR＝1．944，95％ CI：0．994～3.803，P＝0．051）。結論 IL-8基因-251A/T多態性與LOAD髮病風險有一定關繫。
목적：탐토백세포개소8（IL-8）기인-251A/T다태성여신강한족인군지발성아이자해묵병（LOAD）유전역감성적관계。방법선택노년환자80례위LOAD조，동기체검자80례위대조조。채용 PCR-RFLP검측IL-8기인-251A/T다태성분포。결과2조AA기인형분포급A등위기인빈솔비교，차이유통계학의의（16．3％ vs 7．5％， P＝0．035；41．3％ vs 27．5％，P＝0．010）。진일보분석현시，LOAD조A등위기인빈솔가능시LOAD적위험인소（OR＝1．851，95％ CI：1．159～2．957，P＝0．010）；AA기인형환LOAD적위험성시 TT 기인형적3．370배（OR＝3.370，95％ CI：1．143～9．939，P＝0.023）；AT 기인형여 LOAD발병풍험불상관（OR＝1．944，95％ CI：0．994～3.803，P＝0．051）。결론 IL-8기인-251A/T다태성여LOAD발병풍험유일정관계。
Objective To study the relation between IL-8 gene-251A/T polymorphism and delayed Alzheimer's disease (AD)in Xinjiang Han people .Methods Eighty delayed AD patients served as a delayed AD group and 80 subjects undergoing physical examination served as a control group in this study .Distribution of IL-8 gene-251A/T polymorphism in two groups was detected by PCR-RFLP .Results The distribution of genotypes and alleles was different in two groups (P=0 .023 , P= 0 .010) .Further stratified analysis showed that the frequency of A allele was significantly higher in delayed AD group than in control group (OR= 1 .851 ,95% CI:1 .159 -2 .957 ,P=0.010) ,indicating that A allele is the risk factor for delayed AD .The frequency of AA genotype was significantly higher in delayed AD group than in control group (OR=3 .370 ,95% CI:1 .143-9.939 ,P=0 .023) ,indicating that the risk of delayed AD was 3 .370-fold higher in subjects with AA genotype than in those with TT genotype .The AT genotype was not related with the risk of delayed AD (OR=1 .944 ,95% CI:0 .994-3 .803 ,P=0 .051) .Conclusion IL-8 gene-251A/T pol-ymorphism is related with the risk of delayed AD .
