中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
6期
613-616
,共4页
裘丽红%韩新生%苏建%曹华
裘麗紅%韓新生%囌建%曹華
구려홍%한신생%소건%조화
脑血管障碍%糖尿病 ,2型%脑梗死%超声检查 ,多普勒 ,彩色%C反应蛋白质
腦血管障礙%糖尿病 ,2型%腦梗死%超聲檢查 ,多普勒 ,綵色%C反應蛋白質
뇌혈관장애%당뇨병 ,2형%뇌경사%초성검사 ,다보륵 ,채색%C반응단백질
cerebrovascular disorders%diabetes mellitus,type 2%brain infarction%ultrasonography,Doppler,color%C-reactive protein
目的:观察老年2型糖尿病合并缺血性脑血管病(ICVD)患者的临床特点。方法将老年脑梗死患者400例根据有无2型糖尿病分为单纯脑梗死组144例,糖尿病合并急性脑梗死组(合并组)256例,选择同期体检者作为对照组102例。行糖化血红蛋白(HbA1c)和高敏C反应蛋白(Hs-CRP)检测,同时行颈动脉彩色多普勒超声,并测颈动脉内膜中层厚度(IMT),并进行分析。结果合并组和单纯脑梗死组与对照组的HbA1c、hs-CRP水平比较,差异有统计学意义[(8.16±2.47)%和(5.01±1.76)%vs(5.10±1.08)%,(4.23±2.76)ng/L和(3.42±2.02)ng/Lvs(1.50±1.54)ng/L,P<0.05]。年龄、高血压、HbA1c、hs-CRP是动脉粥样硬化发生的独立危险因素。合并组的颈动脉硬化程度较单纯脑梗死组和对照组严重,差异有统计学意义(70.3%vs46.5%和8.8%,P<0.05)。IMT与HbA1c、hs-CRP水平呈正相关(r=0.317,r=0.208,P<0.05)。结论老年2型糖尿病合并ICVD颈动脉粥样斑块与HbA1c、hs-CRP水平密切相关,临床应高度重视。
目的:觀察老年2型糖尿病閤併缺血性腦血管病(ICVD)患者的臨床特點。方法將老年腦梗死患者400例根據有無2型糖尿病分為單純腦梗死組144例,糖尿病閤併急性腦梗死組(閤併組)256例,選擇同期體檢者作為對照組102例。行糖化血紅蛋白(HbA1c)和高敏C反應蛋白(Hs-CRP)檢測,同時行頸動脈綵色多普勒超聲,併測頸動脈內膜中層厚度(IMT),併進行分析。結果閤併組和單純腦梗死組與對照組的HbA1c、hs-CRP水平比較,差異有統計學意義[(8.16±2.47)%和(5.01±1.76)%vs(5.10±1.08)%,(4.23±2.76)ng/L和(3.42±2.02)ng/Lvs(1.50±1.54)ng/L,P<0.05]。年齡、高血壓、HbA1c、hs-CRP是動脈粥樣硬化髮生的獨立危險因素。閤併組的頸動脈硬化程度較單純腦梗死組和對照組嚴重,差異有統計學意義(70.3%vs46.5%和8.8%,P<0.05)。IMT與HbA1c、hs-CRP水平呈正相關(r=0.317,r=0.208,P<0.05)。結論老年2型糖尿病閤併ICVD頸動脈粥樣斑塊與HbA1c、hs-CRP水平密切相關,臨床應高度重視。
목적:관찰노년2형당뇨병합병결혈성뇌혈관병(ICVD)환자적림상특점。방법장노년뇌경사환자400례근거유무2형당뇨병분위단순뇌경사조144례,당뇨병합병급성뇌경사조(합병조)256례,선택동기체검자작위대조조102례。행당화혈홍단백(HbA1c)화고민C반응단백(Hs-CRP)검측,동시행경동맥채색다보륵초성,병측경동맥내막중층후도(IMT),병진행분석。결과합병조화단순뇌경사조여대조조적HbA1c、hs-CRP수평비교,차이유통계학의의[(8.16±2.47)%화(5.01±1.76)%vs(5.10±1.08)%,(4.23±2.76)ng/L화(3.42±2.02)ng/Lvs(1.50±1.54)ng/L,P<0.05]。년령、고혈압、HbA1c、hs-CRP시동맥죽양경화발생적독립위험인소。합병조적경동맥경화정도교단순뇌경사조화대조조엄중,차이유통계학의의(70.3%vs46.5%화8.8%,P<0.05)。IMT여HbA1c、hs-CRP수평정정상관(r=0.317,r=0.208,P<0.05)。결론노년2형당뇨병합병ICVD경동맥죽양반괴여HbA1c、hs-CRP수평밀절상관,림상응고도중시。
Objective To study the clinical features of elderly type 2 diabetic patients with ischemic cerebrovascular disease (ICVD) .Methods Four hundred elderly ischemic stroke patients were di-vided into ischemic stroke group (n=144) ,diabetes plus acute ischemic stroke group (n=256) , and 102 subjects undergoing physical examination served as a control group .Their serum HbA1c and hs-CRP level and carotid IM T were measured .Results The serum HbA1c and hs-CRP levels were significantly different in diabetes plus acute ischemic strore group ,ischemic stroke group and control group [(8 .16 ± 2 .47)% and (5 .01 ± 1 .76)% vs (5 .10 ± 1 .08)% ,(4 .23 ± 2 .76)ng/L and (3.42 ± 2 .02)ng/L vs (1 .50 ± 1 .54)ng/L ,P< 0 .05] .Age ,hypertension ,serum HbA1c and hs-CRP level were the independent risk factors for carotid atherosclerosis .The carotid atheroscle-rosis was severer in diabetes plus acute ischemic stroke group than in ischemic stroke group and control group (70 .3% vs 46 .5% and 8 .8% ,P<0 .05) .The carotid IM T was positively related with the serum HbA1c and hs-CRP level (r=0 .317 ,r=0 .208 ,P<0 .05) .Conclusion Carotid atherosclerotic plaques are closely related with serum HbA 1c and hs-CRP level in elderly type 2 diabetic patients with ICVD .