CAJ | 학술논문

目的：探讨瑞舒伐他汀治疗老年高脂血症患者的疗效和安全性，并与阿托伐他汀进行比较。方法选择2012年6～12月在我院门诊干部诊疗科就诊的老年患者128例，随机分为瑞舒伐他汀组64例（瑞舒伐他汀5 m g/d）和阿托伐他汀组64例（阿托伐他汀10 mg/d），共治疗8周。2组患者继续原发病的常规治疗，停用其他调脂药物2周，以减少对疗效判断的干扰。结果治疗8周后，瑞舒伐他汀组TC、TG和LDL-C下降幅度分别为25．9％、13．5％和33．7％，阿托伐他汀组下降幅度分别为22．6％、12．1％和31．4％，2组下降幅度比较，差异无统计学意义（P＞0．05）。瑞舒伐他汀组与阿托伐他汀组 HDL-C上升幅度差异有统计学意义（9．7％ vs 3．2％，P＜0．05）。2组患者对药物的依从性好，无药物不良反应。结论瑞舒伐他汀5 mg与阿托伐他汀10 mg在降低TC、TG及LDL-C方面相似；瑞舒伐他汀可提高 HDL-C水平，且在老年患者中两者安全性相同。
목적：탐토서서벌타정치료노년고지혈증환자적료효화안전성，병여아탁벌타정진행비교。방법선택2012년6～12월재아원문진간부진료과취진적노년환자128례，수궤분위서서벌타정조64례（서서벌타정5 m g/d）화아탁벌타정조64례（아탁벌타정10 mg/d），공치료8주。2조환자계속원발병적상규치료，정용기타조지약물2주，이감소대료효판단적간우。결과치료8주후，서서벌타정조TC、TG화LDL-C하강폭도분별위25．9％、13．5％화33．7％，아탁벌타정조하강폭도분별위22．6％、12．1％화31．4％，2조하강폭도비교，차이무통계학의의（P＞0．05）。서서벌타정조여아탁벌타정조 HDL-C상승폭도차이유통계학의의（9．7％ vs 3．2％，P＜0．05）。2조환자대약물적의종성호，무약물불량반응。결론서서벌타정5 mg여아탁벌타정10 mg재강저TC、TG급LDL-C방면상사；서서벌타정가제고 HDL-C수평，차재노년환자중량자안전성상동。
Objective To compare the efficacy and safety of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients .Methods One hundred and twenty-eight elderly phyperlipoidemia pa-tients who visited our department from from May 2012 to December 2012 were randomly divided into rosuvastatin treatment group (n=64) and atorvastatin treatment group (n=64) .Patients in rosuvastatin treatment group were treated with rosuvastatin (5 mg/d) and those in atorvastatin treatment group were treated with atorvastatin (10 mg/d) for 8 weeks .Primary hyperlipoidemia received conventional therapy with anti-hyperlipoidemia drugs withdrawn for 2 weeks in order to accurately assess the curative effect of rosuvastatin and atorvastatin .Results No significant difference was found in serum levels of TC ,LDL-C and TG ,although they were lower in rosuvas-tatin treatment group than in atorvastatin treatment group after 8-week treatment (25 .9% vs 22.6% ,33 .7% vs 31 .4% ,13 .5% vs 12 .1% ,P>0 .05) .The serum HDL-C level was significantly higher in rosuvastatin treatment group than in atorvastatin treatment group (9 .7% vs 3 .2% ,P<0 .05) .The drug dependence was good in two groups with no adverse event .Conclusion The effi-ciency and safety of rosuvastatin (5 mg/d) and atorvastatin (10 mg/d) are similar in reducing the serum levels of TC ,TG ,LDL-C ,and rosuvastatin can increase the serum HDL-C level in elderly hyperlipoidemia patients .