CAJ | 학술논문

细胞自噬是细胞在面对内外部环境压力的情况下，为了自身的稳定而采取的一种降解内部及外来入侵物质的机制。SNARE(Soluble N-ethylmaleimide-sensitive factor attachment protein receptors)假说指出SNARE蛋白在细胞物质运输以及特异性膜融合过程中具有重要作用，揭示了细胞正常生理活动有序进行的分子机制。由于细胞自噬涉及从自噬体的形成到自噬体溶酶体的融合等诸多膜融合的过程，因此，文章对近年来 SNARE 蛋白在调控细胞自噬过程的研究进展进行了综述。
세포자서시세포재면대내외부배경압력적정황하，위료자신적은정이채취적일충강해내부급외래입침물질적궤제。SNARE(Soluble N-ethylmaleimide-sensitive factor attachment protein receptors)가설지출SNARE단백재세포물질운수이급특이성막융합과정중구유중요작용，게시료세포정상생리활동유서진행적분자궤제。유우세포자서섭급종자서체적형성도자서체용매체적융합등제다막융합적과정，인차，문장대근년래 SNARE 단백재조공세포자서과정적연구진전진행료종술。
Autophagy is a self-protective mechanism that degrades inner and outer invaded substances to sustain self-maintenance. SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) hypothesis suggests important roles of SNARE proteins in the cellular activities of substance transport and specific membrane fusion, unveiling the molecular mechanisms of normal and physiological activities within a cell. Since autophagy involves membrane fusions from the birth of autophagosomes to the formation of autolysosomes, we review recent research progress on the roles of SNARE proteins in regulating autophagy.